Pioglar-G-Tab

Composition of Pioglar-G-Tab

Pioglar-G-Tab contains Pioglitazone (15mg) + Glimepiride (2mg). It belongs to the Sulfonylurea + Thiazolidinedione (PPAR-gamma agonist) class of medicines.

Uses of Pioglar-G-Tab

Type 2 diabetes mellitus (adult) to improve blood glucose control when diet and exercise alone are not sufficient

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity
• Helps achieve better HbA1c control
• Once-daily combination therapy

How Pioglar-G-Tab works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves glucose utilization. Pioglitazone (a thiazolidinedione/PPAR-γ agonist) improves insulin sensitivity in muscle and fat and reduces hepatic glucose production.

How to take Pioglar-G-Tab

Tablet for oral use. Take exactly as prescribed, usually once daily with the first main meal to reduce risk of low blood sugar. Swallow whole with water; do not skip meals. Regularly monitor blood glucose as advised.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Pioglar-G Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

Taking more Pioglar-G-Tab than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Pioglar-G-Tab

Most side effects of Pioglar-G-Tab are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• dizziness
• headache
• nausea
• weight gain
• oedema (swelling)
• upper respiratory tract infection
• diarrhoea

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Pioglar-G-Tab

Warnings and precautions

Risk of hypoglycaemia (especially if meals are skipped or with other antidiabetics); may cause weight gain and fluid retention—can worsen or precipitate heart failure (avoid in NYHA class III/IV; use caution in cardiac disease); monitor for oedema and shortness of breath. Pioglitazone may increase risk of fractures and can cause/ worsen macular oedema; report vision changes. Use caution in liver disease; check liver enzymes if symptoms of hepatitis occur. Not for type 1 diabetes or diabetic ketoacidosis.

Interactions with other medicines

Other antidiabetic medicines/insulin (increased hypoglycaemia risk), beta-blockers (may mask hypoglycaemia symptoms), rifampicin (may reduce pioglitazone effect), azole antifungals and other CYP2C9 inhibitors like fluconazole (may increase glimepiride effect), gemfibrozil (may increase pioglitazone levels), corticosteroids/thyroid hormones/diuretics (may raise blood glucose)

How to store Pioglar-G-Tab

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Expert advice for Pioglar-G-Tab

Take it as per the dose and duration prescribed by your doctor. Take it with the first main meal of the day (usually breakfast). It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety. Inform your doctor if you notice weight gain, shortness of breath, irregular heartbeat, or any abnormal swelling. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Manufacturer and class

Manufacturer:

SUN PHARMA 2

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Thiazolidinedione (PPAR-gamma agonist)