Pyrigesic MR Tablet

Composition of Pyrigesic MR Tablet

Pyrigesic MR Tablet contains Thiocolchicoside (4mg) + Aceclofenac (100mg) + Paracetamol (325mg). It belongs to the Centrally acting muscle relaxant, Non-steroidal anti-inflammatory drug and Para-aminophenol derivative class of medicines.

Uses of Pyrigesic MR Tablet

• This medicine is used in the treatment of muscle spasm
• back pain
• neck pain
• muscle stiffness
• pain
• inflammation
• arthritis
• fever
• period pain
• headache
• body ache and mild to moderate pain.

Key benefits

• Breaks the spasm–pain cycle
• Helps you move and sleep more comfortably
• Relieves pain and the swelling that causes it
• Effective in arthritis and injury
• The first choice for fever and everyday pain
• Gentle on the stomach
• unlike anti-inflammatory painkillers

How Pyrigesic MR Tablet works

This medicine combines 3 active ingredients: Thiocolchicoside, Aceclofenac and Paracetamol. Thiocolchicoside eases painful muscle spasm by reducing the nerve signals that keep the muscle contracted. Aceclofenac blocks the chemicals your body makes at a site of injury or inflammation, which reduces pain, swelling and fever. Paracetamol reduces fever and relieves pain by acting on the parts of the brain that regulate temperature and register pain.

How to take Pyrigesic MR Tablet

Swallow the tablet whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it with or after food. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause deep drowsiness, muscle weakness, a fall in blood pressure and slowed breathing. It can cause stomach bleeding, kidney failure, drowsiness and fits. It can cause severe and sometimes fatal liver damage, often with no symptoms at all for the first day. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Pyrigesic MR Tablet

Most side effects of Pyrigesic MR are mild and settle as the body adjusts. Reported side effects include:

• Drowsiness
• Dizziness
• Dry mouth
• Weakness
• Nausea
• Indigestion
• Stomach pain
• Heartburn
• Swelling of the ankles and feet
• Rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Pyrigesic MR Tablet

Warnings and precautions

This medicine causes drowsiness. Do not drive or operate machinery until you know how it affects you. Use it for the short course your doctor has prescribed — these are not intended for long-term use. Do not stop a long course abruptly without asking your doctor. Take it with or just after food, and for the shortest time that works. Stop and seek urgent care for black or tarry stools, vomiting blood, or severe stomach pain — this group can cause bleeding from the stomach. Long or high-dose use raises the risk of heart attack, stroke and kidney injury, particularly in older people and those already at risk. Avoid if you are dehydrated or have an illness with vomiting or loose motions — the kidneys are vulnerable then. Must be avoided in the last three months of pregnancy. Never exceed the daily maximum printed on the pack. Paracetamol overdose damages the liver, and the damage can be silent for a day or two before it becomes serious. Check every other medicine you are taking. Paracetamol is in a very large number of cold, flu and pain combinations, and the doses add together. If you drink alcohol regularly, or have liver disease, ask your doctor what daily limit is safe for you. See a doctor if fever lasts more than three days, or pain more than five.

Do not take Pyrigesic MR if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with myasthenia gravis or severe liver disease. Not for people with an active stomach ulcer, severe kidney or heart failure, or asthma triggered by aspirin or anti-inflammatory painkillers. Not in the third trimester of pregnancy. Not for people with severe liver disease, except under medical supervision.

Interactions with other medicines

Alcohol, sleeping tablets, antihistamines and opioid painkillers all add to the drowsiness, sometimes dangerously. Combining with a blood thinner or aspirin sharply raises the bleeding risk. Reduces the effect of blood pressure medicines and water tablets, and together with them can harm the kidneys. Never take two anti-inflammatory painkillers at the same time. Regular alcohol use increases the risk of liver injury. Tell your doctor if you are on warfarin — regular high-dose paracetamol can affect it.

How to store Pyrigesic MR Tablet

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Expert advice for Pyrigesic MR Tablet

Combine it with gentle movement and the physiotherapy your doctor advises; rest alone prolongs back pain. Take it at night if drowsiness troubles you during the day. Use the lowest dose for the shortest period. If you need a painkiller regularly, see your doctor rather than continuing on your own. Paracetamol is the safer choice for simple fever and headache. Take the lowest dose that works, and leave the stated gap between doses. Seek help immediately after a suspected overdose, even if you feel completely well — treatment works best when it is early.

Manufacturer and class

Manufacturer:

EAST INDIA PHARMACEUTICAL WORK

Therapeutic class:

Muscle relaxant, Analgesic and anti-inflammatory and Analgesic and antipyretic

Drug class:

Centrally acting muscle relaxant, Non-steroidal anti-inflammatory drug and Para-aminophenol derivative