Sitaglyn M 50/500 Tablet

Composition of Sitaglyn M 50/500 Tablet

Sitaglyn M 50/500 Tablet contains Sitagliptin 50 mg + Metformin hydrochloride 500 mg (tablet). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Sitaglyn M 50/500 Tablet

Type 2 diabetes mellitus to improve blood glucose control along with diet and exercise; used when single therapy is inadequate.

Key benefits

• Improves fasting and post-meal blood sugar control
• Low risk of hypoglycaemia when used alone
• Helps improve insulin sensitivity
• Supports HbA1c reduction as add-on therapy

How Sitaglyn M 50/500 Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin levels, enhancing glucose-dependent insulin release and reducing glucagon secretion. Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity, lowering blood glucose.

How to take Sitaglyn M 50/500 Tablet

Take orally as prescribed, usually twice daily with meals to reduce stomach upset. Swallow tablet whole with water; do not crush/chew. Follow diet/exercise advice and monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sitaglyn M 50/500 Tablet

Most side effects of Sitaglyn M 50/500 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• upper respiratory tract infection
• hypoglycaemia (especially with other antidiabetics)

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sitaglyn M 50/500 Tablet

Warnings and precautions

Not for type 1 diabetes or diabetic ketoacidosis. Metformin may rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, liver disease, or heavy alcohol use; assess renal function before and during therapy. Temporarily stop metformin before/at time of iodinated contrast studies and major surgery; restart after renal function is stable. Pancreatitis and severe joint pain have been reported with sitagliptin—seek care for persistent severe abdominal pain. Use caution in elderly and in patients with renal impairment; dose adjustment may be needed based on eGFR.

Do not take Sitaglyn M 50/500 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cationic drugs affecting renal tubular secretion (e.g., cimetidine), diuretics and ACE inhibitors/ARBs (may affect renal function), insulin or sulfonylureas (increased hypoglycaemia risk), digoxin (may increase digoxin levels)

How to store Sitaglyn M 50/500 Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Sitaglyn M 50/500 Tablet

It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

ZYDUS HEALTHCARE PHARMA

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide