Skip to main content
PingMeDoc
Prescription requiredAristo Pharmaceuticals Pvt LtdAnxiolytic and hypnotic

Stresnil Plus 10.25 Tablet

Melatonin (3mg) + Alprazolam (0.25mg)

Available at our pharmacy counter

This medicine is dispensed in person against a valid prescription and is not sold online. Ask our pharmacist about availability, or speak to a registered doctor.

In-store reference price ₹86

Stresnil Plus 10.25 Tablet is used for this medicine is used in the treatment of anxiety, insomnia, panic disorder, seizures and muscle spasm.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated October 2026

Licensed pharmacyPharmacist-verified order

Key details

Salt: Melatonin (3mg) + Alprazolam (0.25mg)
Available variants: tablet 3mg + 0.25mg 10`S
Best price: ₹86 (₹8.64 per tablet)
MRP: ₹91
Prescription: Required
Manufacturer: ARISTO PHARMACEUTICALS PVT LTD

Ordering notes

This medicine is dispensed in person at a licensed pharmacy counter and is not delivered.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Same salt, lower price

Medicines with the same active ingredient and strength as Stresnil Plus 10.25 Tablet.

You are viewing

Stresnil Plus 10.25 Tablet

tablet - 3mg + 0.25mg - 10 S

₹86

₹8.64 per tablet

  • Zam-Mt 0.25 Tab

    EAST WEST PHARMA · tablet - 3mg + 0.25mg - 10 S · Rx

    ₹25

    ₹2.51 per tablet

    Save 71%
Compare all substitutes
Same salt, different brand — what does that mean?

A substitute contains the same active ingredient (salt), in the same strength, as Stresnil Plus 10.25 Tablet. The medicine inside is the same — the brand name, manufacturer and price are what differ.

All medicines sold in India, branded or generic, must meet the quality standards set by the national drug regulator (CDSCO). A lower price does not mean lower quality.

Please confirm with your doctor or pharmacist before switching brands — they will check that the strength and form match your prescription.

Composition of Stresnil Plus 10.25 Tablet

Stresnil Plus 10.25 Tablet contains Melatonin (3mg) + Alprazolam (0.25mg). It belongs to the Benzodiazepine / sedative-hypnotic class of medicines.

Uses of Stresnil Plus 10.25 Tablet

  • Anxiety
  • Insomnia
  • Panic disorder
  • Seizures
  • Muscle spasm

Benefits of Stresnil Plus 10.25 Tablet

In Anxiety
Stresnil Plus calms the nervous system quickly, easing acute anxiety, panic and the racing heart and tremor that go with it. It is intended for short-term use.
In Insomnia
Stresnil Plus helps you fall asleep and stay asleep when sleep has broken down, so you can function the next day while the cause is dealt with.
In Panic disorder
Stresnil Plus reduces the frequency and intensity of panic attacks, giving breathing space for longer-term treatment to work.
In Seizures
Stresnil Plus stops a prolonged seizure or a cluster of seizures quickly, and is used in some forms of epilepsy to prevent them.
In Muscle spasm
Stresnil Plus relaxes severe muscle spasm and the pain it causes, including spasm caused by nerve conditions.

How Stresnil Plus 10.25 Tablet works

This medicine combines 2 active ingredients: Melatonin and Alprazolam. Melatonin calms over-activity in the brain, which relieves anxiety and helps sleep come more easily. Alprazolam calms over-activity in the brain, which relieves anxiety and helps sleep come more easily.

How to take Stresnil Plus 10.25 Tablet

Take exactly as prescribed by your doctor.

Side effects of Stresnil Plus 10.25 Tablet

Most side effects of Stresnil Plus are mild and settle as the body gets used to the medicine. The ones reported most often are:

  • Drowsiness
  • Dizziness
  • Unsteadiness
  • Poor concentration
  • Memory lapses
  • Dry mouth

Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Stresnil Plus 10.25 Tablet

AlcoholUNSAFE
Do not drink alcohol while taking this medicine.
PregnancyUNSAFE
Not recommended in pregnancy. It may harm the developing baby, so tell your doctor at once if you are or might be pregnant.
Breast feedingUNSAFE
Not recommended while breastfeeding.
DrivingUNSAFE
Do not drive or operate machinery while taking this medicine.
KidneyCAUTION
Use with caution if you have kidney disease. Your doctor may adjust the dose or monitor your kidney function.
LiverCONSULT YOUR DOCTOR
Consult your doctor if you have liver disease.
Habit formingYES
This medicine can cause dependence with prolonged use. Take it only under medical supervision and do not stop it abruptly.

Warnings and precautions

These medicines cause dependence. They are intended for the shortest possible course — usually two to four weeks — and are not a long-term treatment for anxiety or sleeplessness. Never stop a regular course suddenly. Withdrawal can cause severe anxiety, tremor and fits. Your doctor will taper it slowly. Do not drive or operate machinery. Drowsiness and slowed reactions can continue into the next day. Never combine with alcohol or with opioid painkillers — together they can stop your breathing. Older people are far more likely to fall, become confused or have memory problems on these medicines. Several of these are Schedule H1 medicines and must be dispensed against a prescription and entered in the pharmacy register.

Do not take Stresnil Plus if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe breathing problems, sleep apnoea, or severe liver disease. Not for anyone with a history of dependence, except under specialist supervision.

Interactions with other medicines

Alcohol, opioids, antihistamines, muscle relaxants and other sedatives all deepen the sedation, sometimes fatally.

How to store Stresnil Plus 10.25 Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Quick tips for Stresnil Plus 10.25 Tablet

  • Use it for the shortest course, and ask your doctor about talking therapy and sleep routine, which work without dependence.
  • Take it only at bedtime if it is for sleep, and allow a full night before driving.
  • Never share these medicines, and keep them secured.

Manufacturer and class

Manufacturer:
ARISTO PHARMACEUTICALS PVT LTD
Therapeutic class:
Anxiolytic and hypnotic
Drug class:
Benzodiazepine / sedative-hypnotic

Substitutes for Stresnil Plus 10.25 Tablet

Medicines with the same active ingredient (Melatonin (3mg) + Alprazolam (0.25mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Stresnil Plus 10.25 Tablet
Zam-Mt 0.25 TabletEAST WEST PHARMAtablet · 10`S₹2571% cheaper
See all substitutes and alternatives

More from Aristo Pharmaceuticals Pvt Ltd

View categories
Aceclo 100MG
5% offRx

Aceclo 100MG

Aristo Pharmaceuticals Pvt Ltd - 100 mg - 10 S

₹63.37₹66.70

Save ₹3.33

Prescription required

Aceclo Spas Tab
5% offRx

Aceclo Spas Tab

Aristo Pharmaceuticals Pvt Ltd - Tablet - 80mg + 100mg - 10 S

₹154.38₹162.50

Save ₹8.12

Prescription required

5% offRx

Aceclo SR Tab

Aristo Pharmaceuticals Pvt Ltd - Tablet - 100mg - 10 S

₹95.95₹101

Save ₹5.05

Prescription required

5% offRx

Aceclo-Sera Tab

Aristo Pharmaceuticals Pvt Ltd - Tablet - 10 S

₹131.58₹138.50

Save ₹6.92

Prescription required

Aeromont-B Tab
5% offRx

Aeromont-B Tab

Aristo Pharmaceuticals Pvt Ltd - Tablet - 10 S

₹104.65₹110.15

Save ₹5.50

Prescription required

5% offRx

Alsartan 25MG Tab

Aristo Pharmaceuticals Pvt Ltd - Tablet - 25 mg - 10 S

₹40.08₹42.18

Save ₹2.10

Prescription required

5% offRx

Alsartan 50MG Tab

Aristo Pharmaceuticals Pvt Ltd - Tablet - 50 mg - 10 S

₹79.94₹84.14

Save ₹4.20

Prescription required

5% off

Ambrodil Drops

Aristo Pharmaceuticals Pvt Ltd - Drop - 15 ml

₹46.32₹48.75

Save ₹2.43

More in Anxiety & Sleep

View categories
5% offRx

Alpracad 0.5MG Tab

1 X10

₹22.10₹23.26

Save ₹1.16

Prescription required

Available in store

In-store
5% offRx

Alzolam 0.5

Sun Pharma - 10 S

₹46.32₹48.75

Save ₹2.43

Prescription required

Available in store

In-store
Rx

Anxit -0.5 SR Tab

Micro Labs - Tablet - 0.5mg - 10 S

₹44

Prescription required

Available in store

In-store
Atineu 2MG Tab
5% offRx

Atineu 2MG Tab

Myk Pharmaceuticals - Tablet - 2 mg - 10 S

₹23.60₹24.84

Save ₹1.24

Prescription required

Available in store

In-store
Becalm 0.25MG Tab
5% offRx

Becalm 0.25MG Tab

15

₹16.44₹17.30

Save ₹0.86

Prescription required

Available in store

In-store
Buspin 10 10S
5% offRx

Buspin 10 10S

Intas Pharmaceuticals Ltd - 10 S

₹65.08₹68.50

Save ₹3.42

Prescription required

Available in store

In-store
Cizaspa SR Caps
5% offRx

Cizaspa SR Caps

Lupin Lab - Capsule - 5mg + 135mg - 10 S

₹204.87₹215.65

Save ₹10.78

Prescription required

Available in store

In-store
5% offRx

Cloba Mt 5MG Tab

Intas Pharmaceuticals Ltd - Tablet - 5 mg - 15 S

₹87.23₹91.82

Save ₹4.59

Prescription required

Available in store

In-store

Popular on PingMeDoc Pharmacy

View categories
10% offRx

Zedott Baby Sachet

Torrent Pharmaceuticals Ltd - Powder - 1 G

₹19.49₹21.65

Save ₹2.16

Prescription required

Xyzal Nasal Spray
10% offRx

Xyzal Nasal Spray

Dr Reddys Laboratories Ltd - Spray - 6 G

₹529.46₹588.28

Save ₹58.82

Prescription required

Zeepam Injection
Rx

Zeepam Injection

Tamman Titoe Pharma Pvt Ltd - Injection - 2 ml

₹12.38

Prescription required

Available in store

In-store
Zincolife Syrup
10% offRxOut of stock

Zincolife Syrup

Mankind (Pharma) - Syrup - 50 ml

₹76.07₹84.52

Save ₹8.45

Prescription required

Whisper Ultra Soft 2X Pads Xl
Out of stock

Whisper Ultra Soft 2X Pads Xl

Procter & Gamble Hygiene And Health Care Ltd - 6 Piece

₹70
Zerolac Powder

Zerolac Powder

Raptokos & Brett - Powder - 400 G

₹308
Xyzal Syrup
10% off

Xyzal Syrup

Dr Reddys Laboratories Ltd - Syrup - 60 ml

₹167.49₹186.09

Save ₹18.60

10% offRx

Zerodol Th 4 Tablet

IPCA Laboratories Ltd - Tablet - 10 Tablet

₹226.13₹251.25

Save ₹25.12

Prescription required

Stresnil Plus 10.25 Tablet FAQs

What is Stresnil Plus 10.25 Tablet used for?
Stresnil Plus 10.25 Tablet is commonly used for anxiety, insomnia, panic disorder, seizures and muscle spasm. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What are the benefits of Stresnil Plus 10.25 Tablet?
Anxiety: Stresnil Plus calms the nervous system quickly, easing acute anxiety, panic and the racing heart and tremor that go with it. It is intended for short-term use. It is also used for insomnia, panic disorder, seizures.
What is the salt in Stresnil Plus 10.25 Tablet?
Stresnil Plus 10.25 Tablet contains Melatonin (3mg) + Alprazolam (0.25mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How does Stresnil Plus 10.25 Tablet work?
This medicine combines 2 active ingredients: Melatonin and Alprazolam.
Is Stresnil Plus 10.25 Tablet a prescription medicine?
Yes. Stresnil Plus 10.25 Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Stresnil Plus 10.25 Tablet?
The side effects reported most often with Stresnil Plus are Drowsiness, Dizziness, Unsteadiness, Poor concentration, Memory lapses. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Stresnil Plus 10.25 Tablet be taken during pregnancy?
Stresnil Plus 10.25 Tablet is not recommended in pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Stresnil Plus.
Can I drink alcohol while taking Stresnil Plus 10.25 Tablet?
No. Do not drink alcohol while taking Stresnil Plus 10.25 Tablet.
Is Stresnil Plus 10.25 Tablet habit forming?
Yes. Stresnil Plus 10.25 Tablet can cause dependence with prolonged use. Take Stresnil Plus only as directed and for the duration your doctor advises.
Is there a cheaper substitute for Stresnil Plus 10.25 Tablet?
Zam-Mt 0.25 Tablet has the same active ingredient and strength and is listed from ₹25 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Stresnil Plus 10.25 Tablet cost on PingMeDoc Pharmacy?
Stresnil Plus 10.25 Tablet starts at ₹86 (MRP ₹91) on PingMeDoc Pharmacy. Available in tablet 3mg + 0.25mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Stresnil Plus 10.25 Tablet?
Stresnil Plus 10.25 Tablet is manufactured by ARISTO PHARMACEUTICALS PVT LTD. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Stresnil Plus 10.25 Tablet delivered?
Stresnil Plus 10.25 Tablet is a regulated medicine and is not delivered. It is dispensed in person at a licensed pharmacy counter against a valid prescription. Ask our pharmacist on WhatsApp about availability.

Stresnil Plus 10.25 Tablet, Quick facts

Salt
Melatonin (3mg) + Alprazolam (0.25mg)
Form
tablet
Best price
₹86 (₹8.64 per tablet)
MRP
₹91
Prescription
Required (Rx)
Schedule
Schedule H1
Brand
ARISTO PHARMACEUTICALS PVT LTD
Manufacturer
ARISTO PHARMACEUTICALS PVT LTD
Therapeutic class
Anxiolytic and hypnotic
Drug class
Benzodiazepine / sedative-hypnotic
Habit forming
Yes
Variants
tablet 3mg + 0.25mg 10`S
Delivery
Standard across India

References

Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Stresnil Plus 10.25 Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.