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Prescription requiredSystopic LabGASTRO INTESTINAL

Sysfol Plus

Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg) + Folic Acid (2.5mg)

₹48MRP ₹50In stock

Delivery across India. Free above ₹999; ₹49 from ₹499, ₹99 below. Chennai express delivery is chargeable.

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Sysfol Plus is used for treatment of Nausea and vomiting in pregnancy.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg) + Folic Acid (2.5mg)
Available variants: NA 10`S
Best price: ₹48
MRP: ₹50
Prescription: Required
Manufacturer: SYSTOPIC LAB

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Sysfol Plus

Sysfol Plus contains Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg) + Folic Acid (2.5mg). It belongs to the Anti-emetic / prokinetic and B-complex vitamin class of medicines.

Uses of Sysfol Plus

Treatment of Nausea and vomiting in pregnancy

Key benefits

  • In Treatment of Nausea and vomiting in pregnancy Sysfol Plus Tablet blocks the action of chemicals in the body that can make you feel or be sick during pregnancy. This medicine helps you cope up with nausea or vomiting that occurs due to hormonal changes during pregnancy and helps you complete the term without much discomfort. It also contains nutritional supplements that improve your baby’s immune system
  • enhance the baby’s brain development and also help reduce nausea and vomiting during pregnancy.

How Sysfol Plus works

Sysfol Plus Tablet is a combination of three medicines: doxylamine, vitamin B6 (pyridoxine) and folic acid, which treats nausea and vomiting associated with pregnancy.

How to take Sysfol Plus

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sysfol Plus Tablet is to be taken on an empty stomach.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Sysfol Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause drowsiness, disorientation and abnormal muscle movements. It is unlikely to cause serious harm, because the body passes surplus B vitamins out in the urine. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sysfol Plus

Most side effects of Sysfol Plus are mild and settle as the body adjusts. Reported side effects include:

  • Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sysfol Plus

PregnancyConsult doctor
BreastfeedingBreast feeding CONSULT YOUR DOCTOR
AlcoholUse with caution
DrivingDriving CONSULT YOUR DOCTOR
KidneyKidney CAUTION
LiverLiver CONSULT YOUR DOCTOR
Habit formingNo

Warnings and precautions

Use it for the shortest period that works. These medicines are not intended for long-term daily use. Report any unusual muscle stiffness, tremor, restlessness or uncontrolled movements of the face or limbs at once — stop and contact your doctor. Tell your doctor if you have a heart rhythm problem; some of this group affect the heart's electrical timing. Persistent vomiting needs a diagnosis. Do not keep suppressing it without seeing a doctor, especially with abdominal pain, fever or blood. Tingling, numbness or burning in the hands and feet should be assessed by a doctor rather than self-treated — a supplement does not address the cause. Folic acid can mask a vitamin B12 deficiency while nerve damage continues, so B12 should be checked before taking folic acid long term. Bright yellow urine after a B-complex dose is expected and harmless.

Do not take Sysfol Plus if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with bleeding, blockage or perforation of the gut, or with certain heart rhythm disorders.

Interactions with other medicines

Antifungals, some antibiotics and heart-rhythm medicines increase the risk of rhythm problems when combined. Adds to the drowsiness of alcohol and sedatives. Long-term metformin, acid-reducing medicines and some anti-epileptics lower B12 or folate levels. Tell your doctor if you take levodopa, as vitamin B6 can reduce its effect.

How to store Sysfol Plus

Store at room temperature (below 25°C), protected from moisture and direct light. Keep out of reach of children.

Expert advice for Sysfol Plus

Sysfol Plus Tablet helps treat nausea and vomiting in pregnant women whose symptoms did not improved using diet and lifestyle changes. Take it on an empty stomach with a glass of water. It may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you. Do not take it with other sedating medications such as cough and cold medications as the combination could worsen dizziness leading to falls or other accidents

Manufacturer and class

Manufacturer:
SYSTOPIC LAB
Therapeutic class:
GASTRO INTESTINAL
Drug class:
Anti-emetic / prokinetic and B-complex vitamin

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Sysfol Plus FAQs

What is Sysfol Plus used for?
Sysfol Plus is commonly used for Treatment of Nausea and vomiting in pregnancy. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Sysfol Plus?
Sysfol Plus contains Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg) + Folic Acid (2.5mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Sysfol Plus?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Sysfol Plus work?
Sysfol Plus Tablet is a combination of three medicines: doxylamine, vitamin B6 (pyridoxine) and folic acid, which treats nausea and vomiting associated with pregnancy.
Is Sysfol Plus a prescription medicine?
Yes. Sysfol Plus is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Sysfol Plus?
The side effects reported most often with Sysfol Plus are Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Sysfol Plus be taken during pregnancy?
Consult doctor Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Sysfol Plus.
Can I drink alcohol while taking Sysfol Plus?
Use with caution
What if I miss a dose of Sysfol Plus?
If you miss a dose of Sysfol Plus Tablet, take it as soon as possible.
Is Sysfol Plus habit forming?
No. Sysfol Plus is not known to be habit forming when taken as prescribed.
How much does Sysfol Plus cost on PingMeDoc Pharmacy?
Sysfol Plus starts at ₹48 (MRP ₹50) on PingMeDoc Pharmacy. Available in NA 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Sysfol Plus?
Sysfol Plus is manufactured by SYSTOPIC LAB. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Sysfol Plus delivered?
Sysfol Plus is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Sysfol Plus, Quick facts

Salt
Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg) + Folic Acid (2.5mg)
Best price
₹48
MRP
₹50
Prescription
Required (Rx)
Brand
SYSTOPIC LAB
Manufacturer
SYSTOPIC LAB
Therapeutic class
GASTRO INTESTINAL
Drug class
Anti-emetic / prokinetic and B-complex vitamin
Habit forming
No
Variants
NA 10`S
Delivery
Standard across India

References

The information on Sysfol Plus is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. Manufacturer labeling/pack information
  2. Indian drug/HSN classification references, established medical literature
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Sysfol Plus.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.