Valparin Chrono 500 Tablet

Composition of Valparin Chrono 500 Tablet

Valparin Chrono 500 Tablet contains Sodium Valproate 333 mg + Valproic Acid 145 mg (equivalent to Valproate 500 mg) prolonged/controlled release tablet. It belongs to the Anticonvulsant (Valproate; GABA enhancer) class of medicines.

Uses of Valparin Chrono 500 Tablet

Treatment of epilepsy/seizure disorders (generalised and partial seizures); prevention of migraine (as prescribed); management of manic episodes in bipolar disorder (as prescribed)

Key benefits

• Helps control and prevent seizures
• Provides sustained drug release for longer control
• May prevent migraine attacks (as prescribed)
• Helps manage manic episodes in bipolar disorder (as prescribed)

How Valparin Chrono 500 Tablet works

Valproate increases the level of the inhibitory neurotransmitter GABA in the brain and reduces abnormal electrical activity of neurons. This stabilizes neuronal firing and helps prevent seizures and mood swings.

How to take Valparin Chrono 500 Tablet

Take by mouth exactly as prescribed, preferably at the same time(s) daily. Swallow the prolonged-release tablet whole with water; do not crush, chew or split. Can be taken with or after food to reduce stomach upset.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause deep unconsciousness, slowed breathing and dangerous heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Valparin Chrono 500 Tablet

Most side effects of Valparin Chrono are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• abdominal pain
• diarrhoea
• indigestion
• increased appetite
• weight gain
• tremor
• dizziness
• drowsiness
• headache
• hair loss
• raised liver enzymes

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Valparin Chrono 500 Tablet

Warnings and precautions

Do not stop suddenly without medical advice (risk of seizures). Risk of serious liver injury and pancreatitis—seek urgent care for severe abdominal pain, persistent vomiting, jaundice, dark urine, unusual tiredness. Use with caution in liver disease, mitochondrial disorders, bleeding disorders, kidney impairment, and in the elderly. May cause drowsiness—avoid driving if affected. Monitor liver function tests, blood counts and valproate levels as advised.

Do not take Valparin Chrono if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Valproate-containing medicines are contraindicated in pregnancy for epilepsy unless no alternative exists, and in all women of childbearing potential without a pregnancy prevention programme. Several are not suitable in significant liver disease.

Interactions with other medicines

Carbamazepine, phenytoin, phenobarbital, lamotrigine (increased risk of severe rash), topiramate (risk of hyperammonaemia/encephalopathy), aspirin and other anticoagulants/antiplatelets (bleeding risk), warfarin, benzodiazepines and other CNS depressants, rifampicin, erythromycin, cimetidine

How to store Valparin Chrono 500 Tablet

Store below 25°C in a dry place, protected from moisture and light. Keep in original pack and out of reach of children.

Expert advice for Valparin Chrono 500 Tablet

Take it at the same times every day; a missed dose is a common trigger for a seizure. Keep a seizure diary and take it to your appointments. Tell your doctor before planning a pregnancy — the regimen may need to be changed well in advance. Do not drive until you meet the legal seizure-free period and your doctor agrees.

Manufacturer and class

Manufacturer:

CIPLA LIMITED

Therapeutic class:

Antiepileptic

Drug class:

Anticonvulsant (Valproate; GABA enhancer)