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Dr Reddys Laboratories Ltd - Tablet - 100mg + 325mg + 65mg - 10 S
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Dextromethorphan hydrobromide 10 mg + Guaifenesin 100 mg + Phenylephrine hydrochloride 5 mg per 5 ml
Delivery across India. Free above ₹999; ₹49 from ₹499, ₹99 below. Chennai express delivery is chargeable.
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Zedex-Sf is used for symptomatic relief of dry or productive cough associated with common cold/upper respiratory tract infections; helps relieve chest congestion and nasal stuffiness.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Zedex-Sf contains Dextromethorphan hydrobromide 10 mg + Guaifenesin 100 mg + Phenylephrine hydrochloride 5 mg per 5 ml. It belongs to the Antitussive (NMDA receptor antagonist/central cough suppressant) + Expectorant + Sympathomimetic decongestant class of medicines.
Symptomatic relief of dry or productive cough associated with common cold/upper respiratory tract infections; helps relieve chest congestion and nasal stuffiness.
Dextromethorphan suppresses the cough reflex by acting on the cough center in the brain. Guaifenesin loosens and thins mucus to make coughing out phlegm easier. Phenylephrine is a decongestant that constricts nasal blood vessels to reduce swelling and congestion.
Oral syrup. Shake well before use and measure with a cup/spoon. Usually taken 2–3 times daily as advised by a doctor; may be taken with or without food. Do not exceed the recommended dose and avoid using multiple cough/cold products together.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause vomiting, severe drowsiness, a racing heart and, with codeine, dangerously slow breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Zedex-Sf are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Consult doctor |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Avoid |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Use with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function. |
| Liver | Use with caution if you have liver disease — your doctor may adjust the dose or monitor your liver function. |
| Habit forming | No |
Use with caution in hypertension, heart disease, thyroid disorders, diabetes, glaucoma, enlarged prostate/urinary retention, liver disease and in the elderly. May cause drowsiness—avoid driving or operating machinery if affected. Do not use in children unless prescribed; avoid use with/within 14 days of MAO inhibitors. Seek medical advice if cough persists >7 days, is recurrent, or is accompanied by fever, rash, breathing difficulty, or thick green/yellow sputum.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Codeine-containing preparations are not for children, or for anyone with breathing difficulty.
MAO inhibitors (contraindicated), other serotonergic drugs (SSRIs/SNRIs/TCAs, linezolid) may increase risk of serotonin syndrome with dextromethorphan, alcohol and CNS depressants increase sedation, antihypertensives may have reduced effect with phenylephrine, other decongestants/sympathomimetics may increase BP/heart rate, beta-blockers may increase vasoconstrictive effects
Store below 25°C, protected from light and moisture. Keep bottle tightly closed and out of reach of children.
Drink plenty of water — it thins mucus better than any syrup. Steam inhalation helps congestion and costs nothing. Measure the dose with the cup supplied.

Dr Reddys Laboratories Ltd - Tablet - 100mg + 325mg + 65mg - 10 S
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Prescription required
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The information on Zedex-Sf is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.