Ziomet Life 50/500 Tablet

Composition of Ziomet Life 50/500 Tablet

Ziomet Life 50/500 Tablet contains Sitagliptin 50 mg + Metformin 500 mg (as Metformin Hydrochloride). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Ziomet Life 50/500 Tablet

• Type 2 diabetes mellitus: to improve blood glucose control along with diet and exercise
• when metformin alone is inadequate or as part of combination therapy.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity and reduces hepatic glucose output
• Lowers HbA1c with complementary mechanisms
• Lower hypoglycaemia risk compared to some combinations (unless used with insulin/sulfonylurea)

How Ziomet Life 50/500 Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), leading to increased insulin release and reduced glucagon in a glucose-dependent manner. Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity, reducing blood glucose without usually causing hypoglycaemia when used alone.

How to take Ziomet Life 50/500 Tablet

Take orally as directed by a physician, usually with meals to reduce stomach upset. Swallow tablet whole with water; do not crush/chew unless advised. Take at the same time each day; dose is individualized based on glucose control and kidney function.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Ziomet Life 50/500 as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Ziomet Life 50/500 than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Ziomet Life 50/500 Tablet

Most side effects of Ziomet Life 50/500 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal discomfort
• loss of appetite
• metallic taste
• headache
• upper respiratory tract infection
• hypoglycaemia (especially with insulin/sulfonylureas)
• dizziness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Ziomet Life 50/500 Tablet

Warnings and precautions

Prescription-only. Monitor kidney function before and during therapy; metformin is contraindicated in severe renal impairment and should be used with caution in reduced eGFR. Risk of lactic acidosis (rare but serious), higher with kidney disease, dehydration, severe infection, hypoxia, liver disease, heavy alcohol use; stop and seek urgent care if rapid breathing, severe weakness, abdominal pain occur. Temporarily stop metformin around iodinated contrast procedures and major surgery as advised. Sitagliptin may rarely cause pancreatitis and severe joint pain; discontinue and consult doctor if severe abdominal pain. Monitor for hypersensitivity reactions and signs of heart failure in susceptible patients.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media (temporary interruption), carbonic anhydrase inhibitors e.g. topiramate/acetazolamide (increases metabolic acidosis risk), cationic drugs affecting renal tubular secretion (e.g. cimetidine), insulin and sulfonylureas (increased hypoglycaemia risk; dose adjustment may be needed), diuretics/ACE inhibitors/NSAIDs (may affect renal function), digoxin (sitagliptin may slightly increase digoxin levels)

How to store Ziomet Life 50/500 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Manufacturer and class

Manufacturer:

LIFELINE HEALTHCARE

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide