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Intas Pharmaceuticals Ltd - Tablet - 250mg - 10 S
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Glimepiride 3 mg + Metformin hydrochloride (modified/extended release) 500 mg
Delivered across India in about 3–5 days, Chennai next day. ₹49 delivery, free above ₹999.
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Zoryl Mf 3 is used for type 2 diabetes mellitus (T2DM) in adults when diet and exercise alone or monotherapy is inadequate; helps control blood glucose levels.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Zoryl Mf 3 contains Glimepiride 3 mg + Metformin hydrochloride (modified/extended release) 500 mg. It belongs to the Sulfonylurea + Biguanide (combination) class of medicines.
Type 2 diabetes mellitus (T2DM) in adults when diet and exercise alone or monotherapy is inadequate; helps control blood glucose levels
Glimepiride (a sulfonylurea) increases insulin release from pancreatic beta cells and improves insulin action. Metformin reduces glucose production by the liver and improves insulin sensitivity, decreasing intestinal glucose absorption and improving peripheral uptake.
Oral tablet. Take exactly as prescribed, usually once daily with or immediately after the main meal (often breakfast) to reduce stomach upset and risk of low sugar. Swallow whole (do not crush/chew if modified-release). Monitor blood glucose regularly.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Zoryl Mf are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended (consult doctor; insulin is preferred in pregnancy) |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Avoid |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Risk of hypoglycaemia (especially with missed meals, alcohol, heavy exercise, elderly, renal/hepatic impairment); metformin-associated lactic acidosis risk—avoid in severe kidney disease, severe liver disease, hypoxia, sepsis, dehydration. Check kidney function before and during therapy. Temporarily stop metformin for major surgery or iodinated contrast procedures as advised by doctor. Use caution in heart failure, alcohol use disorder, and in patients with vitamin B12 deficiency (long-term metformin).
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Alcohol (increases hypoglycaemia/lactic acidosis risk), iodinated contrast media, insulin/other antidiabetics (additive hypoglycaemia), sulfonamide antibiotics, fluoroquinolones, beta-blockers (mask hypoglycaemia), corticosteroids and thiazide diuretics (raise glucose), ACE inhibitors (may increase hypoglycaemia), cimetidine (may increase metformin levels), NSAIDs (may increase hypoglycaemia)
Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.
Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.