Glucomust M 5/500 Tablet

Composition of Glucomust M 5/500 Tablet

Glucomust M 5/500 Tablet contains Glipizide 5mg + Metformin 500mg. It belongs to the Sulfonylurea and Biguanide class of medicines.

Uses of Glucomust M 5/500 Tablet

Type 2 diabetes mellitus in adults with inadequate glycaemic control on metformin alone; add-on therapy when fasting and post‑prandial glucose remain elevated despite diet and exercise.

Key benefits

• Lowers blood sugar quickly
• Long-established and inexpensive
• First-choice medicine for type 2 diabetes
• Does not usually cause weight gain
• Low risk of hypoglycaemia when used alone

How Glucomust M 5/500 Tablet works

Glipizide closes pancreatic beta‑cell ATP‑sensitive K+ (KATP; SUR1) channels, depolarising the cell and increasing Ca2+ influx to trigger insulin release. Metformin activates AMP‑activated protein kinase (AMPK), suppressing hepatic gluconeogenesis and improving peripheral insulin sensitivity while decreasing intestinal glucose absorption.

How to take Glucomust M 5/500 Tablet

Glucomust M 5/500 Tablet is usually taken 1 tablet once daily with breakfast or the main meal initially; if prescribed twice daily, take with breakfast and dinner to reduce gastrointestinal upset and hypoglycaemia. Swallow whole with water; do not skip meals after taking the 5mg glipizide/500mg metformin combination.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Glucomust M 5/500 Tablet

Most side effects of Glucomust M 5/500 are mild and settle as the body adjusts. Reported side effects include:

• Common: nausea
• diarrhoea
• abdominal discomfort
• metallic taste
• decreased appetite
• hypoglycaemia (sweating
• tremor
• palpitations)
• weight gain
• headache; Serious: lactic acidosis
• severe/prolonged hypoglycaemia
• cholestatic jaundice/hepatitis
• blood dyscrasias (leukopenia
• thrombocytopenia)
• severe skin reactions (SJS/TEN)
• angioedema.

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Glucomust M 5/500 Tablet

Warnings and precautions

Hypoglycaemia risk is higher with missed meals, heavy exercise, alcohol use, elderly patients, or renal impairment—carry fast‑acting glucose. Metformin component: monitor eGFR before start and periodically; dose review advised when eGFR 30–45 and avoid initiation; stop during dehydration, severe infection, or hypoxic states. Lactic acidosis warning—seek urgent care for rapid breathing, persistent vomiting, severe weakness, abdominal pain. Hepatic impairment increases lactic acidosis/hypoglycaemia risk. Pregnancy: insulin preferred for diabetes management; use only if clinician considers benefit > risk. Breastfeeding: metformin appears in milk in small amounts; glipizide may cause infant hypoglycaemia—medical advice required. Vitamin B12 deficiency can occur with long‑term metformin—periodic B12 assessment in anaemia/neuropathy.

Do not take Glucomust M 5/500 if

Type 1 diabetes mellitus; diabetic ketoacidosis/diabetic coma; eGFR <30 mL/min/1.73m²; acute conditions causing hypoxia (shock, sepsis, acute heart failure, respiratory failure); severe hepatic impairment; history of metformin‑associated lactic acidosis; alcoholism or binge drinking; hypersensitivity to glipizide, metformin or other sulfonylureas; temporarily withhold around iodinated contrast procedures and major surgery as advised.

Interactions with other medicines

Alcohol increases risk of metformin‑associated lactic acidosis and potentiates hypoglycaemia; iodinated contrast media can precipitate acute kidney injury leading to metformin accumulation/lactic acidosis; insulin or other antidiabetics (e.g., linagliptin, empagliflozin) additively increase hypoglycaemia risk; beta‑blockers (e.g., propranolol) mask adrenergic warning signs of hypoglycaemia; fluoroquinolones (e.g., levofloxacin) may cause dysglycaemia; corticosteroids/diuretics (prednisolone, hydrochlorothiazide) raise glucose and reduce efficacy; cimetidine reduces metformin renal clearance via OCT2/MATE inhibition increasing exposure; ACE inhibitors (e.g., enalapril) may enhance glucose‑lowering causing hypoglycaemia in some patients; NSAIDs may increase sulfonylurea effect and hypoglycaemia.

How to store Glucomust M 5/500 Tablet

Store at 20–25°C; protect from moisture and direct light; keep in original blister pack.

Expert advice for Glucomust M 5/500 Tablet

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

Mankind Pharma Ltd

Therapeutic class:

Antidiabetic Combination

Drug class:

Sulfonylurea and Biguanide