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Istamet D XR 1000 mg Tablet
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Tablet
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified order
Key details
Available variants: tablet 1000 mg 7`S
Best price: ₹160 (₹22.80 per tablet)
MRP: ₹168
Prescription: Required
Manufacturer: SUN PHARMA
Ordering notes
Delivery details are shown when the medicine is back in stock.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
How Istamet D XR 1000 mg Tablet works
Istamet 50mg/500mg Tablet is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.
Missed dose and overdose
If you miss a dose
Take the missed dose of Istamet D XR as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.
If you take too much
Taking more Istamet D XR than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.
Side effects of Istamet D XR 1000 mg Tablet
Most side effects of Istamet D XR are mild and settle as the body adjusts. Reported side effects include:
- Diarrhea Nausea Vomiting Stomach upset Headache Nasal congestion Sore throat Respiratory tract infection Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Istamet D XR 1000 mg Tablet
| Pregnancy | Istamet 50mg/500mg Tablet is probably safe to use during pregnancy.Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor. |
|---|---|
| Breastfeeding | Istamet 50mg/500mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby. |
| Alcohol | Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms. |
| Kidney | Istamet 50mg/500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Istamet 50mg/500mg Tablet may be needed. Please consult your doctor.Use of Istamet 50mg/500mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine. |
| Liver | Istamet 50mg/500mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Istamet 50mg/500mg Tablet may not be needed in these patients. Please consult your doctor. |
Interactions with other medicines
Tell your doctor or pharmacist about every medicine you take, including over-the-counter products, vitamins and herbal or ayurvedic preparations, before starting Istamet D XR. Some combinations can change how Istamet D XR works or raise the chance of side effects.
How to store Istamet D XR 1000 mg Tablet
Store Istamet D XR below 30°C in a cool, dry place away from direct sunlight and moisture. Keep the pack tightly closed and out of the reach of children. Do not use it after the expiry date printed on the pack.
Manufacturer and class
- Manufacturer:
- SUN PHARMA
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Istamet D XR 1000 mg Tablet FAQs
What is Istamet D XR 1000 mg Tablet used for?
Istamet D XR 1000 mg Tablet is a medicine available on PingMeDoc Pharmacy. Consult your doctor for the specific indication that applies to you, this page is for educational purposes only.
How does Istamet D XR 1000 mg Tablet work?
Istamet 50mg/500mg Tablet is a combination of two antidiabetic medicines: Sitagliptin and Metformin.
Is Istamet D XR 1000 mg Tablet a prescription medicine?
Yes. Istamet D XR 1000 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Istamet D XR 1000 mg Tablet?
The side effects reported most often with Istamet D XR are Diarrhea
Nausea
Vomiting
Stomach upset
Headache
Nasal congestion
Sore throat
Respiratory tract infection
Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Istamet D XR 1000 mg Tablet be taken during pregnancy?
Istamet 50mg/500mg Tablet is probably safe to use during pregnancy.Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Istamet D XR.
Can I drink alcohol while taking Istamet D XR 1000 mg Tablet?
Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
What if I miss a dose of Istamet D XR 1000 mg Tablet?
Take the missed dose of Istamet D XR as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.
How much does Istamet D XR 1000 mg Tablet cost on PingMeDoc Pharmacy?
Istamet D XR 1000 mg Tablet starts at ₹160 (MRP ₹168) on PingMeDoc Pharmacy. Available in tablet 1000 mg 7`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Istamet D XR 1000 mg Tablet?
Istamet D XR 1000 mg Tablet is manufactured by SUN PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Istamet D XR 1000 mg Tablet delivered?
Istamet D XR 1000 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Istamet D XR 1000 mg Tablet, Quick facts
- Form
- tablet
- Best price
- ₹160 (₹22.80 per tablet)
- MRP
- ₹168
- Prescription
- Required (Rx)
- Brand
- SUN PHARMA
- Manufacturer
- SUN PHARMA
- Variants
- tablet 1000 mg 7`S
- Delivery
- Standard across India
References
The information on Istamet D XR 1000 mg Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Istamet D XR 1000 mg Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.