
Acuclav 375
Macleods Pharmaceuticals Pvt Ltd - 10 S
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Rifampicin (100mg) + Isoniazid (50mg) + Pyrazinamide (300mg)
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Macox Plus Kid is used for this medicine is used in the treatment of tuberculosis.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated October 2026
Macox Plus Kid contains Rifampicin (100mg) + Isoniazid (50mg) + Pyrazinamide (300mg). It belongs to the Anti-tuberculosis agent class of medicines.
This medicine is used in the treatment of tuberculosis.
This medicine combines 3 active ingredients: Rifampicin, Isoniazid and Pyrazinamide. Rifampicin kills the bacteria that cause tuberculosis, over a course lasting several months. Isoniazid kills the bacteria that cause tuberculosis, over a course lasting several months. Pyrazinamide kills the bacteria that cause tuberculosis, over a course lasting several months.
Take exactly as prescribed by your doctor.
Most side effects of Macox Plus Kid are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
TB treatment must be taken every day for the whole course, usually six months or more. Stopping early is the main cause of drug-resistant TB, which is far harder to treat. Rifampicin turns urine, sweat and tears orange-red. This is harmless, but it permanently stains soft contact lenses. Report yellowing of the eyes or skin, dark urine, persistent vomiting or severe tiredness at once — the liver needs checking. Report any change in vision, including colour vision, immediately if you are on ethambutol. Rifampicin makes hormonal contraception unreliable. Use an additional method throughout and for a period after the course.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will adjust or change the regimen in significant liver disease.
Rifampicin reduces the effect of a very large number of medicines, including contraceptives, blood thinners, steroids, some heart and HIV medicines. Vitamin B6 is usually given alongside isoniazid to prevent nerve damage — take it as prescribed.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
People taking Macox Plus Kid are often asked to check these from time to time. Your doctor decides which and how often.

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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.