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Pharmanova - Tablet - 10 S
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Trypsin (48mg) + Bromelain (90mg) + Rutoside (100mg) + Diclofenac (50mg)
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Same composition, in stock now. Check with your doctor or pharmacist before you switch.
Tolby D Tablet is used for pain relief.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Tolby D Tablet contains Trypsin (48mg) + Bromelain (90mg) + Rutoside (100mg) + Diclofenac (50mg). It belongs to the Enzyme / disease-modifying anti-rheumatic agent and Non-steroidal anti-inflammatory drug class of medicines.
Pain relief
Tolby-D Tablet is a combination of four medicines: Trypsin, Bromelain, Rutoside and Diclofenac. Trypsin and Bromelain are enzymes. They increase blood supply and make the body produce substances that fight pain and swelling. Rutoside is an antioxidant which protects the body from damage by chemicals (free radicals) and further reduces swelling. Diclofenac is a non-steroidal antiinflammatory drug (NSAID) which works by blocking the release of certain chemical messengers (prostaglandins) in the brain that cause pain and inflammation (redness and swelling).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tolby-D Tablet is to be taken on an empty stomach.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Tolby-D Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can seriously suppress the bone marrow and damage the liver. It can cause stomach bleeding, kidney failure, drowsiness and fits. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Tolby D are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding UNSAFE |
| Alcohol | Alcohol CONSULT YOUR DOCTOR |
| Driving | Driving CAUTION |
| Kidney | Kidney UNSAFE |
| Liver | Liver UNSAFE |
| Habit forming | No |
Medicines that suppress the immune system need regular blood tests — do not miss them. Report fever, sore throat, mouth ulcers or unusual bruising promptly if you are on an immune-suppressing medicine. Tell your doctor about any infection, and before any vaccination. Methotrexate for arthritis is taken ONCE A WEEK. Taking it daily by mistake is dangerous — check the day on your pack. Take it with or just after food, and for the shortest time that works. Stop and seek urgent care for black or tarry stools, vomiting blood, or severe stomach pain — this group can cause bleeding from the stomach. Long or high-dose use raises the risk of heart attack, stroke and kidney injury, particularly in older people and those already at risk. Avoid if you are dehydrated or have an illness with vomiting or loose motions — the kidneys are vulnerable then. Must be avoided in the last three months of pregnancy.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active serious infection, or with severe liver or bone-marrow disease. Several of these medicines must not be used in pregnancy. Not for people with an active stomach ulcer, severe kidney or heart failure, or asthma triggered by aspirin or anti-inflammatory painkillers. Not in the third trimester of pregnancy.
Tell your doctor about all other medicines, especially anti-inflammatory painkillers and antibiotics. Live vaccines are generally avoided while on immune-suppressing treatment. Combining with a blood thinner or aspirin sharply raises the bleeding risk. Reduces the effect of blood pressure medicines and water tablets, and together with them can harm the kidneys. Never take two anti-inflammatory painkillers at the same time.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Tolby-D Tablet helps relieve pain and inflammation that may occur due to trauma, surgery or everyday activity. It may also be used to relieve inflammation in rheumatic and degenerative conditions, such as rheumatoid arthritis and osteoarthritis. Take it with plenty of fluids, an hour before or two hours after a meal. It may increase the severity of your condition at the start of treatment. Continue using it as prescribed by your doctor. It may cause dizziness and blurred vision. Do not drive or do anything requiring concentration until you know how it affects you. It may change the color, consistency, and odor of your stool. This is harmless. Inform your doctor if this bothers you.
Medicines with the same active ingredient (Trypsin (48mg) + Bromelain (90mg) + Rutoside (100mg) + Diclofenac (50mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Tolby D Tablet |
|---|---|---|---|
| Isibro D TabletEYSYS PHARMA | tablet · 10`S | ₹220 | 9% more |
| Thrize PlusPharmed Ltd | 10`S | ₹290 | 43% more |
| Zymoflam D TabletARISTO PHARMACEUTICALS PVT LTD | tablet · 10`S | ₹309 | 53% more |

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The information on Tolby D Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.