Trulicity 1.5 mg/0.5 ml Injection

Composition of Trulicity 1.5 mg/0.5 ml Injection

Trulicity 1.5 mg/0.5 ml Injection contains Dulaglutide 1.5 mg/0.5 mL solution for injection (pre-filled pen). It belongs to the GLP-1 receptor agonist (incretin mimetic) class of medicines.

Uses of Trulicity 1.5 mg/0.5 ml Injection

Treatment of type 2 diabetes mellitus in adults as an adjunct to diet and exercise to improve glycaemic control; may be used alone or with other antidiabetic medicines. Also used to reduce risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors (as per prescribing information).

Key benefits

• Lowers HbA1c and fasting/post-meal glucose
• Once-weekly dosing
• Lowers appetite and may aid weight loss
• Reduces cardiovascular risk in eligible type 2 diabetes patients
• Can be combined with other antidiabetic therapies

How Trulicity 1.5 mg/0.5 ml Injection works

Dulaglutide is a GLP-1 receptor agonist that increases glucose-dependent insulin secretion and lowers inappropriate glucagon release. It also slows gastric emptying and helps reduce appetite, leading to improved blood sugar control and weight reduction in many patients.

How to take Trulicity 1.5 mg/0.5 ml Injection

For subcutaneous use only (abdomen, thigh, or upper arm). Usually injected once weekly, on the same day each week, with or without food; rotate injection sites and do not inject into a vein or muscle. If a dose is missed, take it within 3 days (72 hours) of the missed dose; otherwise skip and take the next dose on the regular day (follow doctor’s advice).

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause dehydration and a fall in blood pressure. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Trulicity 1.5 mg/0.5 ml Injection

Most side effects of Trulicity are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• decreased appetite
• indigestion
• constipation
• injection site reactions
• headache
• fatigue

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Trulicity 1.5 mg/0.5 ml Injection

Warnings and precautions

Not for type 1 diabetes or treatment of diabetic ketoacidosis. Risk of pancreatitis—seek urgent care for severe persistent abdominal pain (with/without vomiting). May cause hypoglycaemia when used with insulin or sulfonylureas—dose adjustments may be needed. Use caution in severe gastrointestinal disease (e.g., gastroparesis). Possible risk of thyroid C-cell tumors; avoid in patients with personal/family history of medullary thyroid carcinoma or MEN2 (per class warning). Monitor renal function if severe vomiting/diarrhoea occurs (risk of dehydration and worsening kidney function).

Do not take Trulicity if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease.

Interactions with other medicines

Insulin and sulfonylureas (increased hypoglycaemia risk), medicines requiring rapid GI absorption (dulaglutide may delay gastric emptying and affect absorption), other GLP-1 receptor agonists (generally avoid duplication)

How to store Trulicity 1.5 mg/0.5 ml Injection

Store refrigerated at 2°C to 8°C; do not freeze. Keep in original carton to protect from light. If allowed by label, may be kept at room temperature (up to 30°C) for a limited period; discard if stored outside recommended conditions or past expiry.

Expert advice for Trulicity 1.5 mg/0.5 ml Injection

Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine.

Manufacturer and class

Manufacturer:

CIPLA LIMITED

Therapeutic class:

Antidiabetic

Drug class:

GLP-1 receptor agonist (incretin mimetic)