Zensita -D 50/5 mg Tablet

Composition of Zensita -D 50/5 mg Tablet

Zensita -D 50/5 mg Tablet contains Dapagliflozin (5mg) + Sitagliptin (50mg). It belongs to the DPP-4 inhibitor + SGLT2 inhibitor class of medicines.

Uses of Zensita -D 50/5 mg Tablet

Type 2 diabetes mellitus (as an add-on to diet and exercise) to improve glycaemic control in adults when dual therapy is appropriate.

Key benefits

• Lowers fasting and post-meal blood glucose
• Helps reduce HbA1c
• Low risk of hypoglycaemia when used without insulin/sulfonylurea
• May aid modest weight reduction
• Once-daily convenient therapy

How Zensita -D 50/5 mg Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones, thereby increasing insulin release and decreasing glucagon levels in a glucose-dependent manner. Dapagliflozin is an SGLT2 inhibitor that lowers blood glucose by increasing urinary glucose excretion through the kidneys.

How to take Zensita -D 50/5 mg Tablet

Tablet for oral use. Take as prescribed by the doctor, usually once daily; may be taken with or without food, preferably at the same time each day. Maintain adequate hydration; follow diet/exercise advice and monitor blood glucose.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zensita-D 50/5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause dehydration and a fall in blood pressure. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zensita -D 50/5 mg Tablet

Most side effects of Zensita -D 50/5 mg are mild and settle as the body adjusts. Reported side effects include:

• Genital fungal infection
• urinary tract infection
• increased urination
• thirst
• headache
• nasopharyngitis
• dizziness
• nausea
• constipation
• low blood sugar (especially with insulin/sulfonylurea)

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zensita -D 50/5 mg Tablet

Warnings and precautions

Not for type 1 diabetes or diabetic ketoacidosis. Risk of dehydration and low blood pressure (more in elderly/diuretics); maintain fluids. SGLT2 inhibitors may increase risk of genital mycotic infections, UTIs and rare Fournier’s gangrene—seek care for genital pain/swelling/fever. Rare risk of pancreatitis with sitagliptin—stop and consult if severe abdominal pain occurs. Monitor kidney function before and during therapy; use with caution/avoid in significant renal impairment as advised by physician. Use caution if history of recurrent UTIs, ketoacidosis, alcoholism, low-carb intake, or surgery/acute illness (ketoacidosis risk).

Do not take Zensita -D 50/5 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease.

Interactions with other medicines

Insulin and sulfonylureas (increased hypoglycaemia risk),diuretics (increased dehydration/hypotension risk),rifampicin and other strong enzyme inducers (may reduce sitagliptin effect),digoxin (sitagliptin may increase levels),other glucose-lowering drugs (additive effect)

How to store Zensita -D 50/5 mg Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Zensita -D 50/5 mg Tablet

Zensita-D 50/5 Tablet is used alone or together with other diabetes medicines to control blood sugar and avoid long-term complications. It also reduces the risk of heart attack, heart failure, or other cardiovascular events. You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) along with Zensita-D 50/5 Tablet. It may cause your body to lose too much fluid (dehydration), or you may urinate more often. Drink plenty of water and stay hydrated. It can cause genital fungal and/or urinary tract infections (UTIs) in both females and males, so practice good hygiene. It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol, or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool, pale skin, tremor, and anxiety. Inform your doctor immediately if you experience constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting. Monitor your blood sugar regularly while taking this medicine.

Manufacturer and class

Manufacturer:

ZUVENTUS HEALTHCARE LTD`

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + SGLT2 inhibitor