Zinodap M5/1000 SR

Composition of Zinodap M5/1000 SR

Zinodap M5/1000 SR contains Dapagliflozin 10 mg + Metformin (as Metformin Hydrochloride) 1000 mg (Sustained Release). It belongs to the SGLT2 inhibitor + Biguanide class of medicines.

Uses of Zinodap M5/1000 SR

• Type 2 diabetes mellitus: to improve glycaemic control in adults as an adjunct to diet and exercise
• when dual therapy with metformin and an SGLT2 inhibitor is appropriate

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves HbA1c control with dual mechanism
• Sustained-release metformin for better GI tolerance
• May aid modest weight reduction
• Lowers risk of hypoglycaemia when not used with insulin/secretagogues

How Zinodap M5/1000 SR works

Dapagliflozin is an SGLT2 inhibitor that reduces glucose reabsorption in the kidneys, increasing urinary glucose excretion. Metformin decreases hepatic glucose production and improves insulin sensitivity; the SR form releases drug slowly to improve GI tolerability and provide prolonged effect.

How to take Zinodap M5/1000 SR

Oral tablet (SR). Take exactly as prescribed, usually once daily with a meal (preferably with/after the main meal) to reduce stomach upset. Swallow whole; do not crush, chew or break. Maintain adequate hydration.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zinodap M5/1000 SR as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zinodap M5/1000 SR than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zinodap M5/1000 SR

Most side effects of Zinodap M5/1000 SR are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal discomfort
• decreased appetite
• headache
• increased urination
• genital fungal infection
• urinary tract infection
• dizziness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zinodap M5/1000 SR

Warnings and precautions

Not for type 1 diabetes. Risk of lactic acidosis with metformin (higher risk in severe kidney impairment, dehydration, sepsis, hypoxia, alcohol abuse); stop and seek care for rapid breathing, severe weakness, abdominal pain. Dapagliflozin may cause genital mycotic infections, UTIs, volume depletion/low BP, and rarely ketoacidosis (can occur with normal sugars); stop and seek care for nausea, vomiting, abdominal pain, rapid breathing. Assess kidney function before and periodically; dose/use may be restricted in reduced eGFR. Withhold before major surgery and during acute illness or prolonged fasting; restart when stable and eating. Use caution in elderly, on diuretics, or with low BP. Consider vitamin B12 monitoring with long-term metformin. Inform doctor before iodinated contrast procedures; may need temporary discontinuation.

Interactions with other medicines

Insulin and sulfonylureas (increased hypoglycaemia risk), diuretics (increased dehydration/low BP risk), ACE inhibitors/ARBs (may enhance BP lowering), NSAIDs and nephrotoxic drugs (worsen renal function affecting metformin safety), alcohol (increases lactic acidosis risk), iodinated contrast media (risk of lactic acidosis—temporary stop), cationic drugs affecting renal tubular secretion e.g. cimetidine (may increase metformin levels)

How to store Zinodap M5/1000 SR

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Manufacturer and class

Manufacturer:

WOCHARDT PHARMA

Therapeutic class:

Antidiabetic

Drug class:

SGLT2 inhibitor + Biguanide