Zomelis Met 50/850 mg Tablet

Composition of Zomelis Met 50/850 mg Tablet

Zomelis Met 50/850 mg Tablet contains Sitagliptin 50 mg + Metformin Hydrochloride 850 mg (as immediate-release tablet). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Zomelis Met 50/850 mg Tablet

Type 2 diabetes mellitus: to improve glycaemic control in adults when diet and exercise alone or metformin/sitagliptin monotherapy is inadequate.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves HbA1c control
• Low risk of hypoglycaemia when not combined with insulin/sulfonylurea
• Helps improve insulin sensitivity

How Zomelis Met 50/850 mg Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), leading to glucose-dependent increased insulin release and reduced glucagon. Metformin decreases hepatic glucose production and improves insulin sensitivity, reducing glucose absorption and improving peripheral uptake.

How to take Zomelis Met 50/850 mg Tablet

Take exactly as prescribed. Usually taken orally with meals to reduce stomach upset; swallow tablet whole with water. Do not crush/chew unless advised. Dose is individualized based on kidney function and blood sugar; follow your doctor’s schedule.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zomelis Met 50/850 mg Tablet

Most side effects of Zomelis Met 50/850 mg are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• upper respiratory tract infection
• nasopharyngitis

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zomelis Met 50/850 mg Tablet

Warnings and precautions

Prescription only. Risk of lactic acidosis with metformin (medical emergency): higher risk in kidney impairment, dehydration, severe infection, hypoxia, heart failure, liver disease, or excess alcohol; stop and seek help if fast breathing, severe weakness, muscle pain, abdominal pain, or drowsiness occur. Assess renal function before and during therapy; dose adjustment/avoid in significant renal impairment. Temporarily stop metformin before iodinated contrast procedures and major surgery as advised. Sitagliptin: rare pancreatitis and severe joint pain; stop and consult if severe persistent abdominal pain. Monitor for hypoglycaemia if used with insulin/sulfonylureas.

Do not take Zomelis Met 50/850 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cationic drugs that reduce metformin clearance (e.g., cimetidine), insulin/sulfonylureas (increased hypoglycaemia risk), digoxin (sitagliptin may slightly increase levels)

How to store Zomelis Met 50/850 mg Tablet

Store below 25°C, protected from moisture and light. Keep in original blister pack and out of reach of children.

Expert advice for Zomelis Met 50/850 mg Tablet

It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

ERIS LIFE SCIENCES PVT LTD

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide