Zoryl M2 Forte

Composition of Zoryl M2 Forte

Zoryl M2 Forte contains Glimepiride 2 mg + Metformin hydrochloride 1000 mg (sustained release). It belongs to the Sulfonylurea + Biguanide (Metformin SR combination) class of medicines.

Uses of Zoryl M2 Forte

Type 2 diabetes mellitus (in adults) when blood sugar is not adequately controlled with diet/exercise and single-agent therapy; helps control fasting and post-meal glucose.

Key benefits

• Controls fasting and post-meal blood sugar
• Improves insulin secretion and sensitivity
• Helps reduce insulin resistance
• May aid in preventing diabetes-related complications with good control

How Zoryl M2 Forte works

Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves insulin action. Metformin reduces glucose production in the liver and improves insulin sensitivity, decreasing glucose absorption and improving peripheral uptake. Together they provide better glycaemic control than either alone.

How to take Zoryl M2 Forte

Take by mouth as prescribed, usually once daily with the first main meal (or as advised). Swallow the tablet whole; do not crush or chew (SR). Regularly monitor blood glucose; follow diet and exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zoryl M2 Forte as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zoryl M2 Forte than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zoryl M2 Forte

Most side effects of Zoryl M2 Forte are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl M2 Forte

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, strenuous exercise, alcohol, elderly). Metformin can rarely cause lactic acidosis—risk increases with kidney impairment, severe infection, dehydration, shock, or hypoxia; avoid if severe renal dysfunction. Check kidney function before and during therapy; use caution in liver disease and heart failure. Stop temporarily before iodinated contrast imaging and major surgery as advised by doctor. Long-term metformin may reduce vitamin B12 levels; monitor if anaemia/neuropathy.

Interactions with other medicines

Alcohol (increases hypoglycaemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia), corticosteroids/thiazide diuretics (raise glucose), ACE inhibitors (may enhance glucose-lowering), fluoroquinolones (glucose disturbances), rifampicin (reduces effect), azole antifungals/clarithromycin (increase sulfonylurea effect), NSAIDs/salicylates (increase hypoglycaemia risk), iodinated contrast media (lactic acidosis risk)

How to store Zoryl M2 Forte

Store below 25°C in a dry place, protected from moisture and light. Keep out of reach of children.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide (Metformin SR combination)