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Prescription requiredIntas Pharmaceuticals LtdAntidiabetic
Zoryl-Md 1/500 mg Tablet
Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride)
₹127MRP ₹1345% offIn stock
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Zoryl-Md 1/500 mg Tablet is used for treatment of type 2 diabetes mellitus in adults when diet and exercise alone or monotherapy is insufficient; helps control high blood sugar.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride)
Available variants: tablet 1mg + 500mg 10`S
Best price: ₹127 (₹12.74 per tablet)
MRP: ₹134
Prescription: Required
Manufacturer: INTAS PHARMACEUTICALS`
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Zoryl-Md 1/500 mg Tablet in Bangladesh
8 brands registered in Bangladesh with the same salt, strength and form.
- Dieta M 1Pacific Pharmaceuticals Ltd.
- Duocon SR 1/500Incepta Pharmaceuticals Ltd.
- Gemer 1Sun Pharmaceutical (Bangladesh) Ltd.
- Glimitus M 1 + 500Ziska Pharmaceuticals Ltd.
- GLIMS M 1/500 MGOpsonin Pharma Limited
- Limaryl M 1/500Popular Pharmaceuticals PLC
- Limpet-M 1Drug International Ltd.
- Secrin M 1/500Square Pharmaceuticals PLC, Gazipur
Brand names differ between countries. Ask a pharmacist or your doctor in Bangladesh before switching. We don't sell or ship these brands. Source: Directorate General of Drug Administration, Bangladesh.
Same salt, lower price
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Zoryl-Md 1/500 mg Tablet
tablet - 1mg + 500mg - 10 S
₹127
₹12.74 per tablet
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Same salt, different brand — what does that mean?
A substitute contains the same active ingredient (salt), in the same strength, as Zoryl-Md 1/500 mg Tablet. The medicine inside is the same — the brand name, manufacturer and price are what differ.
All medicines sold in India, branded or generic, must meet the quality standards set by the national drug regulator (CDSCO). A lower price does not mean lower quality.
Please confirm with your doctor or pharmacist before switching brands — they will check that the strength and form match your prescription.
Composition of Zoryl-Md 1/500 mg Tablet
Zoryl-Md 1/500 mg Tablet contains Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride). It belongs to the Sulfonylurea + Biguanide (antidiabetic combination) class of medicines.
Uses of Zoryl-Md 1/500 mg Tablet
Treatment of type 2 diabetes mellitus in adults when diet and exercise alone or monotherapy is insufficient; helps control high blood sugar.
Key benefits
- Lowers fasting and post-meal blood sugar
- Improves insulin sensitivity
- Reduces liver glucose production
- Helps achieve better HbA1c control
- Supports long-term diabetes complication risk reduction with control
How Zoryl-Md 1/500 mg Tablet works
Glimepiride is a sulfonylurea that stimulates the pancreas to release insulin and improves insulin utilization. Metformin reduces glucose production in the liver and improves insulin sensitivity, lowering blood glucose levels.
How to take Zoryl-Md 1/500 mg Tablet
Take by mouth exactly as prescribed, usually once daily with breakfast or the first main meal to reduce stomach upset. Swallow the tablet as directed; do not skip meals to avoid low blood sugar. Dose is individualized based on blood glucose and tolerance.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Zoryl-Md 1/500 mg Tablet
Most side effects of Zoryl-Md 1/500 mg are mild and settle as the body adjusts. Reported side effects include:
- Hypoglycaemia (low blood sugar)
- nausea
- vomiting
- diarrhoea
- abdominal discomfort
- loss of appetite
- headache
- dizziness
- weight gain
- metallic taste
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Zoryl-Md 1/500 mg Tablet
| Pregnancy | Not recommended; consult doctor (insulin is generally preferred in pregnancy). |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Avoid (increases risk of hypoglycaemia and metformin-associated lactic acidosis). |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Warnings and precautions
Risk of hypoglycaemia (higher with missed meals, excess exercise, alcohol, or other antidiabetics); monitor blood glucose regularly. Metformin may rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, unusual muscle pain, abdominal pain, or drowsiness; risk increases with kidney/liver disease, dehydration, severe infection, heart failure, or heavy alcohol use. Use with caution/avoid in significant renal impairment; kidney function should be checked before and during therapy. Withhold metformin temporarily around iodinated contrast studies and major surgery as advised by a doctor. Not for type 1 diabetes or diabetic ketoacidosis.
Do not take Zoryl-Md 1/500 mg if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Interactions with other medicines
Alcohol, insulin and other antidiabetics (risk of hypoglycaemia), beta-blockers (may mask hypoglycaemia), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide diuretics (may raise glucose), rifampicin (may reduce effect), fluconazole and other CYP2C9 inhibitors (may increase glimepiride effect), iodinated contrast media (lactic acidosis risk), cimetidine (may increase metformin levels)
How to store Zoryl-Md 1/500 mg Tablet
Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.
Expert advice for Zoryl-Md 1/500 mg Tablet
Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.
Manufacturer and class
- Manufacturer:
- INTAS PHARMACEUTICALS`
- Therapeutic class:
- Antidiabetic
- Drug class:
- Sulfonylurea + Biguanide (antidiabetic combination)
Substitutes for Zoryl-Md 1/500 mg Tablet
Medicines with the same active ingredient (Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Zoryl-Md 1/500 mg Tablet |
|---|---|---|---|
| Glimison M1 TabletUNISON PHARMACEUTICALS | tablet · 15`S | ₹38 | 70% cheaper |
| Zoryl-1Intas Pharmaceuticals Ltd | 15`S | ₹59 | 54% cheaper |
| Icarmet G2ICARUS HEALTHCARE | 10`S | ₹67 | 48% cheaper |
| Yogamet gm 1 TabletHIGLANCE | tablet · 10`S | ₹70 | 45% cheaper |
| Gride M TabletEAST WEST PHARMA | tablet · 10`S | ₹75 | 41% cheaper |
| Glidot-M1 TabletMEDI DOT IN PHARMA | tablet · 15`S | ₹87 | 32% cheaper |
| Zetaglim-M1 TabletELINOR PHARMACEUTICALS PVT LTD | tablet · 15`S | ₹87 | 31% cheaper |
| Glimilan GM1 TabletCLEVELAND PHARMACEUTICALS | tablet · 10`S | ₹87 | 31% cheaper |
| Glisimet M1 TabletEYSYS PHARMA | tablet · 14`S | ₹91 | 28% cheaper |
| Glimibrit M 1 TabletElbrit LIfe Sciences | tablet · 15 Tablet | ₹101 | 21% cheaper |
| Glimibrit M1 ForteElbrit LIfe Sciences | 15`S | ₹110 | 14% cheaper |
| Aristomet G1 Tablet | 1X15 | ₹124 | 3% cheaper |
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Zoryl-Md 1/500 mg Tablet FAQs
What is Zoryl-Md 1/500 mg Tablet used for?
Zoryl-Md 1/500 mg Tablet is commonly used for Treatment of type 2 diabetes mellitus in adults when diet and exercise alone or monotherapy is insufficient; helps control high blood sugar. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Zoryl-Md 1/500 mg Tablet?
Zoryl-Md 1/500 mg Tablet contains Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Zoryl-Md 1/500 mg Tablet?
Take by mouth exactly as prescribed, usually once daily with breakfast or the first main meal to reduce stomach upset. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Zoryl-Md 1/500 mg Tablet work?
Glimepiride is a sulfonylurea that stimulates the pancreas to release insulin and improves insulin utilization.
Is Zoryl-Md 1/500 mg Tablet a prescription medicine?
Yes. Zoryl-Md 1/500 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Zoryl-Md 1/500 mg Tablet?
The side effects reported most often with Zoryl-Md 1/500 mg are Hypoglycaemia (low blood sugar), nausea, vomiting, diarrhoea, abdominal discomfort. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Zoryl-Md 1/500 mg Tablet be taken during pregnancy?
Not recommended; consult doctor (insulin is generally preferred in pregnancy). Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Zoryl-Md 1/500 mg.
Can I drink alcohol while taking Zoryl-Md 1/500 mg Tablet?
Avoid (increases risk of hypoglycaemia and metformin-associated lactic acidosis).
What if I miss a dose of Zoryl-Md 1/500 mg Tablet?
Take it as soon as you remember.
Is Zoryl-Md 1/500 mg Tablet habit forming?
No. Zoryl-Md 1/500 mg Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Zoryl-Md 1/500 mg Tablet?
Glimison M1 Tablet has the same active ingredient and strength and is listed from ₹38 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Zoryl-Md 1/500 mg Tablet cost on PingMeDoc Pharmacy?
Zoryl-Md 1/500 mg Tablet starts at ₹127 (MRP ₹134) on PingMeDoc Pharmacy. Available in tablet 1mg + 500mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Zoryl-Md 1/500 mg Tablet?
Zoryl-Md 1/500 mg Tablet is manufactured by INTAS PHARMACEUTICALS`. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Zoryl-Md 1/500 mg Tablet delivered?
Zoryl-Md 1/500 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Zoryl-Md 1/500 mg Tablet, Quick facts
- Salt
- Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride)
- Form
- tablet
- Best price
- ₹127 (₹12.74 per tablet)
- MRP
- ₹134
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Brand
- Intas Pharmaceuticals Ltd
- Manufacturer
- INTAS PHARMACEUTICALS`
- Therapeutic class
- Antidiabetic
- Drug class
- Sulfonylurea + Biguanide (antidiabetic combination)
- Habit forming
- No
- Variants
- tablet 1mg + 500mg 10`S
- Delivery
- Standard across India
References
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.
- Manufacturer labeling, established medical literature (standard pharmacology)
- CDSCO/Indian drug regulatory labeling practices
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Zoryl-Md 1/500 mg Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.