Zoryl-Md 1/500 mg Tablet

Composition of Zoryl-Md 1/500 mg Tablet

Zoryl-Md 1/500 mg Tablet contains Glimepiride 1 mg + Metformin 500 mg (as Metformin hydrochloride). It belongs to the Sulfonylurea + Biguanide (antidiabetic combination) class of medicines.

Uses of Zoryl-Md 1/500 mg Tablet

Treatment of type 2 diabetes mellitus in adults when diet and exercise alone or monotherapy is insufficient; helps control high blood sugar.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity
• Reduces liver glucose production
• Helps achieve better HbA1c control
• Supports long-term diabetes complication risk reduction with control

How Zoryl-Md 1/500 mg Tablet works

Glimepiride is a sulfonylurea that stimulates the pancreas to release insulin and improves insulin utilization. Metformin reduces glucose production in the liver and improves insulin sensitivity, lowering blood glucose levels.

How to take Zoryl-Md 1/500 mg Tablet

Take by mouth exactly as prescribed, usually once daily with breakfast or the first main meal to reduce stomach upset. Swallow the tablet as directed; do not skip meals to avoid low blood sugar. Dose is individualized based on blood glucose and tolerance.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zoryl-Md 1/500 mg as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zoryl-Md 1/500 mg than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zoryl-Md 1/500 mg Tablet

Most side effects of Zoryl-Md 1/500 mg are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia (low blood sugar)
• nausea
• vomiting
• diarrhoea
• abdominal discomfort
• loss of appetite
• headache
• dizziness
• weight gain
• metallic taste

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl-Md 1/500 mg Tablet

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, excess exercise, alcohol, or other antidiabetics); monitor blood glucose regularly. Metformin may rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, unusual muscle pain, abdominal pain, or drowsiness; risk increases with kidney/liver disease, dehydration, severe infection, heart failure, or heavy alcohol use. Use with caution/avoid in significant renal impairment; kidney function should be checked before and during therapy. Withhold metformin temporarily around iodinated contrast studies and major surgery as advised by a doctor. Not for type 1 diabetes or diabetic ketoacidosis.

Interactions with other medicines

Alcohol, insulin and other antidiabetics (risk of hypoglycaemia), beta-blockers (may mask hypoglycaemia), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide diuretics (may raise glucose), rifampicin (may reduce effect), fluconazole and other CYP2C9 inhibitors (may increase glimepiride effect), iodinated contrast media (lactic acidosis risk), cimetidine (may increase metformin levels)

How to store Zoryl-Md 1/500 mg Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide (antidiabetic combination)