Zoryl-1

Composition of Zoryl-1

Zoryl-1 contains Glimepiride (1mg) + Metformin (500mg). It belongs to the Sulfonylurea class of medicines.

Uses of Zoryl-1

• Treatment of type 2 diabetes mellitus in adults
• as an adjunct to diet and exercise to help control blood sugar; may be used alone or with other antidiabetic medicines as prescribed.

Key benefits

• Helps lower fasting and post-meal blood sugar
• Improves glycaemic control in type 2 diabetes
• Reduces symptoms of high blood sugar when used with diet and exercise
• Convenient once-daily dosing

How Zoryl-1 works

Glimepiride is a sulfonylurea antidiabetic. It lowers blood glucose mainly by stimulating insulin release from pancreatic beta cells and may also improve peripheral insulin sensitivity.

How to take Zoryl-1

Tablet for oral use. Take exactly as prescribed, usually once daily with breakfast or the first main meal; swallow whole with water. Do not skip meals; monitor blood glucose regularly and follow diet/exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zoryl-1

Most side effects of Zoryl-1 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• dizziness
• headache
• nausea
• abdominal pain
• diarrhoea
• weight gain
• skin rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl-1

Warnings and precautions

Can cause hypoglycaemia (risk higher with missed meals, excessive exercise, alcohol, elderly, kidney/liver impairment); use with caution in renal or hepatic disease; avoid driving/operating machinery if symptoms of low sugar occur. Inform doctor about G6PD deficiency (risk of haemolysis with sulfonylureas). Not for type 1 diabetes or diabetic ketoacidosis. Discuss if you are fasting or have major surgery/acute illness; dose adjustments may be needed.

Do not take Zoryl-1 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Other antidiabetics/insulin (increased hypoglycaemia risk), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide diuretics (may increase blood sugar), fluconazole/miconazole (may increase effect), rifampicin (may reduce effect), NSAIDs and salicylates (may increase effect), warfarin (possible altered anticoagulant effect)

How to store Zoryl-1

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Zoryl-1

You have been prescribed this combination medicine as it can control blood sugar better than metformin alone. You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Zoryl-M 1 Tablet PR. Take it with food to lower your chance of having an upset stomach. Monitor your blood sugar level regularly while you are taking this medicine.  Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic. It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.  Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Zoryl-M 1 Tablet PR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea