Coversyl Plus

Composition of Coversyl Plus

Coversyl Plus contains Perindopril erbumine 4 mg + Indapamide 1.25 mg (per tablet). It belongs to the ACE inhibitor + Thiazide-like diuretic class of medicines.

Uses of Coversyl Plus

• Treatment of hypertension (high blood pressure)
• especially when combination therapy is required; may be used to reduce cardiovascular risk in suitable patients as prescribed.

Key benefits

• Lowers high blood pressure effectively
• Reduces risk of heart and kidney complications of hypertension
• Combination therapy improves BP control vs single agent
• Once-daily dosing for better adherence

How Coversyl Plus works

Perindopril is an ACE inhibitor that relaxes blood vessels by reducing formation of angiotensin II, lowering blood pressure and strain on the heart. Indapamide is a thiazide-like diuretic that helps the body remove excess salt and water, further reducing blood pressure.

How to take Coversyl Plus

Oral tablet. Usually taken once daily in the morning, preferably before food, as directed by the doctor. Swallow whole with water; do not stop abruptly without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause a severe fall in blood pressure, with dizziness, fainting and a fast or slow pulse. It can cause severe dehydration, a sharp fall in blood pressure and dangerous salt imbalances. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Coversyl Plus

Most side effects of Coversyl Plus are mild and settle as the body adjusts. Reported side effects include:

• dizziness
• headache
• dry cough
• low blood pressure
• fatigue
• nausea
• abdominal pain
• increased urination
• low potassium or sodium
• muscle cramps
• raised creatinine

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Coversyl Plus

Warnings and precautions

Prescription medicine. Can cause hypotension, especially after the first dose or in dehydrated patients; maintain hydration. Monitor kidney function and electrolytes (potassium, sodium) periodically. Risk of angioedema (swelling of face/lips/tongue) with ACE inhibitors—seek urgent care if it occurs. Not recommended in pregnancy; can harm the fetus. Use caution in renal impairment, elderly, severe heart failure, liver disease, gout, diabetes, or if on salt substitutes containing potassium. Stop and consult doctor if persistent severe cough, fainting, or severe vomiting/diarrhea occurs.

Do not take Coversyl Plus if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be used in pregnancy — it can seriously harm the developing baby. Not for people with narrowing of both kidney arteries, or a history of swelling of the face and throat caused by this group of medicines. Not for people who are unable to pass urine, or who are severely dehydrated.

Interactions with other medicines

Potassium supplements/salt substitutes and potassium-sparing diuretics (e.g., spironolactone, eplerenone) increasing hyperkalemia risk, other antihypertensives and diuretics (additive hypotension), NSAIDs (reduced antihypertensive effect and kidney risk), lithium (toxicity risk), aliskiren/ARBs (increased renal impairment/hyperkalemia risk), corticosteroids and laxatives (electrolyte imbalance), antidiabetic medicines (may need monitoring), alcohol (increased dizziness)

How to store Coversyl Plus

Store below 25°C in a dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Coversyl Plus

Blood pressure medicines work only while you take them — do not stop because you feel well. Tell your doctor at once if you become pregnant or are planning a pregnancy. Keep a home blood-pressure record if your doctor has asked for one. Weigh yourself at the same time each day if you have heart failure, and report a rapid gain. Do not add extra salt, and ask before using a potassium-based salt substitute.

Manufacturer and class

Manufacturer:

SERDIA PHARMACEUTICALS`

Therapeutic class:

Antihypertensive

Drug class:

ACE inhibitor + Thiazide-like diuretic