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Sun Pharma - Capsule - 15 S
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Dapagliflozin 5 mg + Glimepiride 2 mg + Metformin 500 mg (as Metformin HCl) per tablet
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Gemerdapa 5/2/500 Tablet is used for type 2 diabetes mellitus: to improve blood glucose control in adults when diet and exercise alone or current therapy is inadequate.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated October 2026
Gemerdapa 5/2/500 Tablet contains Dapagliflozin 5 mg + Glimepiride 2 mg + Metformin 500 mg (as Metformin HCl) per tablet. It belongs to the SGLT2 inhibitor + Sulfonylurea + Biguanide class of medicines.
Type 2 diabetes mellitus: to improve blood glucose control in adults when diet and exercise alone or current therapy is inadequate.
Metformin decreases hepatic glucose production and improves insulin sensitivity. Glimepiride (a sulfonylurea) increases insulin release from pancreatic beta cells. Dapagliflozin (an SGLT2 inhibitor) increases urinary glucose excretion by reducing glucose reabsorption in the kidneys.
Oral tablet; take exactly as prescribed by the doctor, usually once daily with food (preferably with the first main meal) to reduce stomach upset. Swallow whole with water; do not crush/chew. Monitor blood glucose regularly.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause dehydration and a fall in blood pressure. It can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Gemerdapa 5/2/500 are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended; consult doctor (insulin preferred in pregnancy). |
|---|---|
| Breastfeeding | Not recommended while breastfeeding. |
| Alcohol | Avoid or use with caution; increases risk of hypoglycaemia and metformin-associated lactic acidosis. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Risk of hypoglycaemia (higher with missed meals, alcohol, heavy exercise or with other antidiabetics); metformin-associated lactic acidosis (seek urgent care for rapid breathing, severe weakness, abdominal pain); stop metformin temporarily before/after iodinated contrast procedures and during severe illness/dehydration; dapagliflozin may cause dehydration/low BP, ketoacidosis (can occur with normal sugars), serious genital infections; monitor renal function—use not recommended in severe kidney impairment; caution in elderly and those on diuretics; not for type 1 diabetes.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Insulin/other sulfonylureas (increased hypoglycaemia), diuretics (increased dehydration/hypotension), ACE inhibitors/ARBs (may enhance glucose lowering), corticosteroids and sympathomimetics (raise glucose), rifampicin (may reduce glimepiride effect), azole antifungals/clarithromycin (may increase glimepiride effect), alcohol (increases hypoglycaemia and lactic acidosis risk), iodinated contrast media (lactic acidosis risk with metformin), carbonic anhydrase inhibitors like topiramate (may increase acidosis risk)
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine. Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.