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Prescription requiredAnti-diabetic
Istamet G IR 50/500/2 Tablet
Glimepiride (2mg) + Metformin (500mg) + Sitagliptin (50mg)
₹134MRP ₹14910% offIn stock
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Istamet G IR 50/500/2 Tablet is used for this medicine is used in the treatment of type 2 diabetes.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated October 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Glimepiride (2mg) + Metformin (500mg) + Sitagliptin (50mg)
Available variants: tablet 10 Tablet
Best price: ₹134 (₹13.41 per tablet)
MRP: ₹149
Prescription: Required
Manufacturer: Sun Pharma Laboratories Ltd
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Composition of Istamet G IR 50/500/2 Tablet
Istamet G IR 50/500/2 Tablet contains Glimepiride (2mg) + Metformin (500mg) + Sitagliptin (50mg). It belongs to the Sulfonylurea, Biguanide and DPP-4 inhibitor class of medicines.
Uses of Istamet G IR 50/500/2 Tablet
This medicine is used in the treatment of type 2 diabetes.
Benefits of Istamet G IR 50/500/2 Tablet
- In Type 2 diabetes
- Istamet G IR 50/500/2 prompts your pancreas to release more insulin, bringing high sugar readings down quickly. Steady control lowers the long-term risk of damage to the eyes, kidneys, nerves and blood vessels.
How Istamet G IR 50/500/2 Tablet works
This medicine combines 3 active ingredients: Glimepiride, Metformin and Sitagliptin. Glimepiride lowers blood sugar by prompting your pancreas to release more of its own insulin. Metformin lowers blood sugar by reducing the amount of glucose your liver releases and by helping your muscles respond better to your own insulin. It does not force your pancreas to make more insulin, which is why it rarely causes low blood sugar on its own. Sitagliptin lowers blood sugar by protecting the natural gut hormones that tell your pancreas to release insulin after a meal, so the effect is strongest when your sugar is highest.
How to take Istamet G IR 50/500/2 Tablet
Swallow the tablet whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it shortly before a meal. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Istamet G IR 50/500/2 Tablet
Most side effects of Istamet G IR 50/500/2 are mild and settle as the body gets used to the medicine. The ones reported most often are:
- Low blood sugar
- Weight gain
- Nausea
- Dizziness
- Headache
- Loose motions
- Stomach pain
- Metallic taste
- Loss of appetite
- Flatulence
- Sore throat
- Blocked or runny nose
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Istamet G IR 50/500/2 Tablet
- AlcoholUNSAFE
- Do not drink alcohol while taking this medicine.
- PregnancyUNSAFE
- Not recommended in pregnancy. It may harm the developing baby, so tell your doctor at once if you are or might be pregnant.
- Breast feedingCONSULT YOUR DOCTOR
- Consult your doctor before using this while breastfeeding.
- DrivingCAUTION
- May cause drowsiness or affect your concentration. Do not drive until you know how it affects you.
- KidneyCONSULT YOUR DOCTOR
- Consult your doctor if you have kidney disease.
- LiverCONSULT YOUR DOCTOR
- Consult your doctor if you have liver disease.
Warnings and precautions
If you feel shaky, sweaty, confused or unusually hungry, take sugar, glucose or a sweet drink at once and tell your doctor — these are signs your blood sugar has fallen too low. Do not skip meals while on this medicine — a missed meal is the commonest cause of a low-sugar episode. Carry glucose, sugar or sweets with you, and tell the people you live and work with what a low-sugar episode looks like. Older people and people with kidney trouble are more likely to have low sugar, and may need a smaller dose. Stomach upset is common in the first two weeks and usually settles; taking it with food helps. Tell your doctor before any surgery or a scan that uses contrast dye — this medicine is usually stopped for a short time around them. Stop and seek urgent care if you develop deep rapid breathing, severe weakness, muscle pain or vomiting with cold clammy skin. This is rare but serious. Long-term use can lower vitamin B12, so your doctor may check it from time to time. Stop and see a doctor urgently if you get severe, persistent abdominal pain that spreads to your back, with or without vomiting. Tell your doctor if you develop severe or disabling joint pain. Blisters or peeling of the skin should be reported promptly.
Do not take Istamet G IR 50/500/2 if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Interactions with other medicines
Many medicines change how strongly this works — tell your doctor about aspirin, blood thinners, antifungals, sulfa antibiotics and beta blockers in particular. Beta blockers can mask the warning signs of low blood sugar. Tell your doctor about water tablets, steroids, and any contrast dye scan. Alcohol increases the risk of the rare acid build-up and should be limited. Low blood sugar is more likely when this is combined with a sulfonylurea or insulin; your doctor may lower that dose.
How to store Istamet G IR 50/500/2 Tablet
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Quick tips for Istamet G IR 50/500/2 Tablet
- Take it shortly before a meal, and eat that meal.
- Check your sugar as often as your doctor has asked, especially when your routine changes.
- Take it with or just after food to reduce stomach upset.
- Keep taking it even when your sugar readings look normal.
- That is the medicine working.
- Continue your diet and physical activity; this medicine works alongside them, not instead of them.
- It can be taken with or without food, at the same time each day.
- Keep up your diet and activity.
Related lab tests
People taking Istamet G IR 50/500/2 are often asked to check these from time to time. Your doctor decides which and how often.
Manufacturer and class
- Manufacturer:
- Sun Pharma Laboratories Ltd
- Therapeutic class:
- Anti-diabetic
- Drug class:
- Sulfonylurea, Biguanide and DPP-4 inhibitor
Substitutes for Istamet G IR 50/500/2 Tablet
Medicines with the same active ingredient (Glimepiride (2mg) + Metformin (500mg) + Sitagliptin (50mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Istamet G IR 50/500/2 Tablet |
|---|---|---|---|
| Gemer Sita Ir 50/500/1 mg TabletSUN PHARMA | tablet · 10`S | ₹138 | 3% more |
| Glimiprime Sm2 TabletPRIMUS PHARMA | tablet · 10`S | ₹138 | 3% more |
| Istamet G-Ir 50/500/2 mg TabletSUN PHARMA | tablet · 10`S | ₹145 | 8% more |
| Glisen Sm 2/50/500 mg TabletALEMBIC PHARMA | tablet · 10`S | ₹149 | 11% more |
| Gluconorm-Gs 2 mg TabletLUPIN LAB | tablet · 10`S | ₹161 | 20% more |
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Istamet G IR 50/500/2 Tablet FAQs
What is Istamet G IR 50/500/2 Tablet used for?
Istamet G IR 50/500/2 Tablet is commonly used for type 2 diabetes. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What are the benefits of Istamet G IR 50/500/2 Tablet?
Type 2 diabetes: Istamet G IR 50/500/2 prompts your pancreas to release more insulin, bringing high sugar readings down quickly. Steady control lowers the long-term risk of damage to the eyes, kidneys, nerves and blood vessels.
What is the salt in Istamet G IR 50/500/2 Tablet?
Istamet G IR 50/500/2 Tablet contains Glimepiride (2mg) + Metformin (500mg) + Sitagliptin (50mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Istamet G IR 50/500/2 Tablet?
Swallow the tablet whole with a glass of water. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Istamet G IR 50/500/2 Tablet work?
This medicine combines 3 active ingredients: Glimepiride, Metformin and Sitagliptin.
Is Istamet G IR 50/500/2 Tablet a prescription medicine?
Yes. Istamet G IR 50/500/2 Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Istamet G IR 50/500/2 Tablet?
The side effects reported most often with Istamet G IR 50/500/2 are Low blood sugar, Weight gain, Nausea, Dizziness, Headache. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Istamet G IR 50/500/2 Tablet be taken during pregnancy?
Istamet G IR 50/500/2 Tablet is not recommended in pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Istamet G IR 50/500/2.
Can I drink alcohol while taking Istamet G IR 50/500/2 Tablet?
No. Do not drink alcohol while taking Istamet G IR 50/500/2 Tablet.
What if I miss a dose of Istamet G IR 50/500/2 Tablet?
Take it as soon as you remember.
Is Istamet G IR 50/500/2 Tablet habit forming?
No. Istamet G IR 50/500/2 Tablet is not known to be habit forming when taken as prescribed.
How much does Istamet G IR 50/500/2 Tablet cost on PingMeDoc Pharmacy?
Istamet G IR 50/500/2 Tablet starts at ₹134 (MRP ₹149) on PingMeDoc Pharmacy. Available in tablet 10 Tablet. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Istamet G IR 50/500/2 Tablet?
Istamet G IR 50/500/2 Tablet is manufactured by Sun Pharma Laboratories Ltd. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Istamet G IR 50/500/2 Tablet delivered?
Istamet G IR 50/500/2 Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Istamet G IR 50/500/2 Tablet, Quick facts
- Salt
- Glimepiride (2mg) + Metformin (500mg) + Sitagliptin (50mg)
- Form
- tablet
- Best price
- ₹134 (₹13.41 per tablet)
- MRP
- ₹149
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Manufacturer
- Sun Pharma Laboratories Ltd
- Therapeutic class
- Anti-diabetic
- Drug class
- Sulfonylurea, Biguanide and DPP-4 inhibitor
- Habit forming
- No
- Variants
- tablet 10 Tablet
- Delivery
- Standard across India
References
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.
- PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
- CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Istamet G IR 50/500/2 Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.