
Acuclav 375
Macleods Pharmaceuticals Pvt Ltd - 10 S
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Metoprolol Succinate (25mg) + Hydrochlorothiazide (12.5mg)
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Metomac 25 is used for hypertension (high blood pressure).
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Metomac 25 contains Metoprolol Succinate (25mg) + Hydrochlorothiazide (12.5mg). It belongs to the Beta blocker and Water tablet class of medicines.
Hypertension (high blood pressure)
Metomac H 25mg/12.5mg Tablet is a combination of two blood-pressure lowering medicines: Metoprolol Succinate and Hydrochlorothiazide. Metoprolol Succinate is a beta blocker which works specifically on the heart to reduce heart rate and make the heart more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metomac H 25mg/12.5mg Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Metomac H 25mg/12.5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause a dangerously slow heartbeat, a severe fall in blood pressure, wheezing and fits. It can cause severe dehydration, a sharp fall in blood pressure and dangerous salt imbalances. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Metomac are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding CAUTION |
| Alcohol | Alcohol CAUTION |
| Driving | Driving UNSAFE |
| Kidney | Kidney UNSAFE |
| Liver | Liver CAUTION |
| Habit forming | No |
Never stop this medicine suddenly. Stopping abruptly can cause a sharp rise in blood pressure, worsening chest pain or a heart attack — your doctor will reduce it gradually. Tell your doctor if you have asthma or long-standing lung disease; this group can tighten the airways. If you have diabetes, be aware that this medicine can mask the early warning signs of low blood sugar, apart from sweating. Report a resting pulse that is persistently very slow, or fainting. Take it in the morning so that passing urine does not disturb your sleep. Your doctor will check your salts and kidney function with blood tests — do not skip them. Report muscle cramps, marked weakness, confusion or an irregular heartbeat; these can be signs your potassium or sodium has fallen. In hot weather or during an illness with vomiting or loose motions, tell your doctor — you may become dehydrated quickly.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with a very slow heart rate, certain heart block disorders, or uncontrolled heart failure. Generally avoided in severe asthma. Not for people who are unable to pass urine, or who are severely dehydrated.
Combining with verapamil or diltiazem can slow the heart dangerously. Tell your doctor about diabetes medicines and about any asthma inhaler. Anti-inflammatory painkillers blunt the effect and can strain the kidneys. Lithium and digoxin levels are affected; tell your doctor if you take either. Potassium-sparing types must not be combined with potassium supplements without supervision.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
It is a combination of two blood pressure lowering medications used for the treatment of high blood pressure. It can be taken with or without food. Do not stop taking Metomac H 25mg/12.5mg Tablet suddenly as it can cause your blood pressure to rise suddenly thereby increasing the risk of heart attack and stroke. It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position. It can hide symptoms of low blood sugar if you're diabetic. Monitor your blood sugar levels regularly. Metomac H 25mg/12.5mg Tablet may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.

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The information on Metomac 25 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.