Mpabliss M 12.5/1000 mg Tablet

Composition of Mpabliss M 12.5/1000 mg Tablet

Mpabliss M 12.5/1000 mg Tablet contains Metoprolol succinate 12.5 mg + Metformin hydrochloride 1000 mg. It belongs to the Biguanide + Selective beta-1 adrenergic blocker class of medicines.

Uses of Mpabliss M 12.5/1000 mg Tablet

Management of type 2 diabetes mellitus with co-existing hypertension/angina; helps control blood sugar along with control of blood pressure/heart rate as prescribed by doctor.

Key benefits

• Lowers high blood sugar in type 2 diabetes
• Improves insulin sensitivity and reduces hepatic glucose output
• Helps control blood pressure and heart rate
• May reduce angina symptoms and cardiac workload

How Mpabliss M 12.5/1000 mg Tablet works

Metformin reduces glucose production in the liver, decreases intestinal glucose absorption and improves insulin sensitivity, lowering blood sugar. Metoprolol is a selective beta-1 blocker that reduces heart rate and cardiac workload, thereby lowering blood pressure and relieving angina symptoms.

How to take Mpabliss M 12.5/1000 mg Tablet

Oral tablet. Take exactly as prescribed, usually once daily with food (preferably after a meal) to reduce stomach upset. Swallow whole with water; do not crush/chew unless advised. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause a dangerously slow heartbeat, a severe fall in blood pressure, wheezing and fits. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Mpabliss M 12.5/1000 mg Tablet

Most side effects of Mpabliss M 12.5/1000 mg are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal discomfort
• loss of appetite
• metallic taste
• dizziness
• tiredness
• slow heart rate
• cold hands/feet
• headache

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Mpabliss M 12.5/1000 mg Tablet

Warnings and precautions

Prescription medicine. Metformin: risk of lactic acidosis (seek urgent care for rapid breathing, severe weakness, abdominal pain); use caution in kidney impairment, liver disease, dehydration, severe infection, and before/after contrast dye procedures—doctor may temporarily stop it. Metoprolol: may cause bradycardia/low BP; do not stop abruptly (risk of rebound hypertension/angina); use caution in asthma/COPD, heart block, heart failure, and diabetes (may mask hypoglycaemia symptoms). Use with caution in elderly. Not for type 1 diabetes or diabetic ketoacidosis.

Do not take Mpabliss M 12.5/1000 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with a very slow heart rate, certain heart block disorders, or uncontrolled heart failure. Generally avoided in severe asthma. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk),iodinated contrast media,other antidiabetics/insulin (hypoglycaemia),diuretics (may affect glucose control/kidney function),ACE inhibitors/ARBs (may enhance glucose lowering),NSAIDs (kidney risk),calcium channel blockers (verapamil/diltiazem) and digoxin (bradycardia),other beta-blockers,clonidine (rebound BP on withdrawal),CYP2D6 inhibitors like fluoxetine/paroxetine/quinidine (increase metoprolol levels)

How to store Mpabliss M 12.5/1000 mg Tablet

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Expert advice for Mpabliss M 12.5/1000 mg Tablet

Take it at the same time each day and do not miss doses. Learn to check your own pulse, and report a persistently slow one. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

PRIMUS PHARMA

Therapeutic class:

Antidiabetic + Antihypertensive

Drug class:

Biguanide + Selective beta-1 adrenergic blocker