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Prescription requiredCipla LimitedAnti-emetic and Anti-ulcer agent

Neksium 20 Tablet

Domperidone (30mg) + Esomeprazole (20mg)

Neksium 20 Tablet is used for this medicine is used in the treatment of nausea, vomiting, bloating, slow stomach emptying, acidity, acid reflux, stomach ulcer and heartburn.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

₹150₹9.98 per tablet
Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Domperidone (30mg) + Esomeprazole (20mg)
Available variants: tablet tablet 15`S
Best price: ₹150 (₹9.98 per tablet)
Prescription: Required
Manufacturer: CIPLA LIMITED

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Neksium 20 Tablet

Neksium 20 Tablet contains Domperidone (30mg) + Esomeprazole (20mg). It belongs to the Anti-emetic / prokinetic and Proton pump inhibitor class of medicines.

Uses of Neksium 20 Tablet

  • This medicine is used in the treatment of nausea
  • vomiting
  • bloating
  • slow stomach emptying
  • acidity
  • acid reflux
  • stomach ulcer and heartburn.

Key benefits

  • Rapid relief of nausea and vomiting
  • Helps bloating and early fullness
  • Powerful and reliable relief of acidity
  • Heals ulcers and reflux damage
  • Usually taken once a day

How Neksium 20 Tablet works

Neksium D 20 Capsules is a combination of two medicines: Domperidone and Esomeprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Esomeprazole is a proton pump inhibitor (ppi) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

How to take Neksium 20 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Esonix-DSR Capsule is to be taken empty stomach.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause drowsiness, disorientation and abnormal muscle movements. It may cause confusion, blurred vision, sweating and a fast heartbeat. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Neksium 20 Tablet

Most side effects of Neksium are mild and settle as the body adjusts. Reported side effects include:

  • Dry mouth
  • Drowsiness
  • Headache
  • Loose motions
  • Restlessness
  • Nausea
  • Stomach pain
  • Flatulence

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Neksium 20 Tablet

PregnancyNeksium D 20 Capsules may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
BreastfeedingNeksium D 20 Capsules is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
AlcoholCaution is advised when consuming alcohol with Neksium D 20 Capsules . Please consult your doctor.
DrivingMay cause drowsiness or affect your concentration. Do not drive until you know how it affects you.
KidneyEsonix-DSR Capsule should be used with caution in patients with kidney disease. Dose adjustment of Esonix-DSR Capsule may be needed. Please consult your doctor.
LiverEsonix-DSR Capsule should be used with caution in patients with liver disease. Dose adjustment of Esonix-DSR Capsule may be needed. Please consult your doctor.Use of Esonix-DSR Capsule is not recommended in patients with moderate and severe liver disease.
Habit formingNo

Warnings and precautions

Use it for the shortest period that works. These medicines are not intended for long-term daily use. Report any unusual muscle stiffness, tremor, restlessness or uncontrolled movements of the face or limbs at once — stop and contact your doctor. Tell your doctor if you have a heart rhythm problem; some of this group affect the heart's electrical timing. Persistent vomiting needs a diagnosis. Do not keep suppressing it without seeing a doctor, especially with abdominal pain, fever or blood. Take it on an empty stomach, about half an hour to an hour before your first meal — this is when the acid pumps are most active and the medicine works best. Long-term use has been linked to low magnesium and low vitamin B12, and to a higher risk of bone fracture. Review the need with your doctor rather than continuing indefinitely. Tell your doctor if acidity comes with difficulty swallowing, vomiting, weight loss, or black stools — these need investigation, not a longer course. Do not stop a long course abruptly; acid can rebound. Your doctor will taper it.

Do not take Neksium if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with bleeding, blockage or perforation of the gut, or with certain heart rhythm disorders.

Interactions with other medicines

Antifungals, some antibiotics and heart-rhythm medicines increase the risk of rhythm problems when combined. Adds to the drowsiness of alcohol and sedatives. Reduces the absorption of some antifungals, iron and certain HIV medicines. Tell your doctor if you take clopidogrel, methotrexate or a blood thinner.

How to store Neksium 20 Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Neksium 20 Tablet

Take it shortly before meals for bloating and early fullness. Sip fluids frequently in small amounts, and use oral rehydration salts if you have been vomiting. Take it before breakfast, not after a meal. Eat smaller meals, avoid late dinners, raise the head of your bed and avoid smoking — these do as much as the tablet for reflux.

Manufacturer and class

Manufacturer:
CIPLA LIMITED
Therapeutic class:
Anti-emetic and Anti-ulcer agent
Drug class:
Anti-emetic / prokinetic and Proton pump inhibitor

Substitutes for Neksium 20 Tablet

Medicines with the same active ingredient (Domperidone (30mg) + Esomeprazole (20mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Neksium 20 Tablet
Esomac D 20 CapsuleCIPLA LIMITEDcapsule · 10`S₹13311% cheaper
Nexpro Rd 20 CapsuleTorrent Pharmaceuticals Ltdcapsule · 10`S₹1407% cheaper
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Neksium 20 Tablet FAQs

What is Neksium 20 Tablet used for?
Neksium 20 Tablet is commonly used for This medicine is used in the treatment of nausea, vomiting, bloating, slow stomach emptying, acidity, acid reflux, stomach ulcer and heartburn. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Neksium 20 Tablet?
Neksium 20 Tablet contains Domperidone (30mg) + Esomeprazole (20mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Neksium 20 Tablet?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Neksium 20 Tablet work?
Neksium D 20 Capsules is a combination of two medicines: Domperidone and Esomeprazole.
Is Neksium 20 Tablet a prescription medicine?
Yes. Neksium 20 Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Neksium 20 Tablet?
The side effects reported most often with Neksium are Dry mouth, Drowsiness, Headache, Loose motions, Restlessness. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Neksium 20 Tablet be taken during pregnancy?
Neksium D 20 Capsules may be unsafe to use during pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Neksium.
Can I drink alcohol while taking Neksium 20 Tablet?
Caution is advised when consuming alcohol with Neksium D 20 Capsules .
What if I miss a dose of Neksium 20 Tablet?
Take it as soon as you remember.
Is Neksium 20 Tablet habit forming?
No. Neksium 20 Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Neksium 20 Tablet?
Esomac D 20 Capsule has the same active ingredient and strength and is listed from ₹133 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Neksium 20 Tablet cost on PingMeDoc Pharmacy?
Neksium 20 Tablet starts at ₹150 on PingMeDoc Pharmacy. Available in tablet tablet 15`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Neksium 20 Tablet?
Neksium 20 Tablet is manufactured by CIPLA LIMITED. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Neksium 20 Tablet delivered?
Neksium 20 Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Neksium 20 Tablet, Quick facts

Salt
Domperidone (30mg) + Esomeprazole (20mg)
Form
tablet
Best price
₹150 (₹9.98 per tablet)
Prescription
Required (Rx)
Schedule
Schedule H
Brand
CIPLA LIMITED
Manufacturer
CIPLA LIMITED
Therapeutic class
Anti-emetic and Anti-ulcer agent
Drug class
Anti-emetic / prokinetic and Proton pump inhibitor
Habit forming
No
Variants
tablet tablet 15`S
Delivery
Standard across India

References

The information on Neksium 20 Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Neksium 20 Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.