Sita M ER 50/1000 Tablet

Composition of Sita M ER 50/1000 Tablet

Sita M ER 50/1000 Tablet contains Sitagliptin (50mg) + Metformin (500mg). It belongs to the DPP-4 inhibitor + Biguanide (metformin) class of medicines.

Uses of Sita M ER 50/1000 Tablet

Type 2 diabetes mellitus: to improve blood glucose control in adults when diet and exercise alone are not sufficient; used as combination therapy (often when metformin alone is inadequate).

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin response without significant hypoglycemia when used alone
• Extended-release metformin improves tolerability and once-daily dosing
• May help improve HbA1c when metformin alone is insufficient

How Sita M ER 50/1000 Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin levels (GLP-1, GIP), enhancing glucose-dependent insulin release and reducing glucagon. Metformin reduces hepatic glucose production and improves insulin sensitivity; the ER form provides prolonged release to help reduce GI side effects.

How to take Sita M ER 50/1000 Tablet

Oral tablet (extended-release). Take exactly as prescribed, usually once daily with the evening meal; swallow whole without crushing/chewing/breaking. Take with food to reduce stomach upset; maintain diet/exercise and monitor blood glucose.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Sita OD MSR 50/500 Tablet ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sita M ER 50/1000 Tablet

Most side effects of Sita M ER 50/1000 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhea
• abdominal discomfort
• loss of appetite
• headache
• upper respiratory tract infection
• nasopharyngitis
• flatulence
• metallic taste

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sita M ER 50/1000 Tablet

Warnings and precautions

Type 2 diabetes only (not for type 1 diabetes or diabetic ketoacidosis). Risk of lactic acidosis with metformin—avoid in severe kidney impairment; assess eGFR before and during therapy. Temporarily stop metformin around iodinated contrast studies or major surgery as advised. Use caution with liver disease, dehydration, heavy alcohol use, heart failure, and in elderly. Sitagliptin may rarely cause pancreatitis or severe joint pain; seek medical help for severe abdominal pain. Watch for hypoglycemia when used with insulin or sulfonylureas. Vitamin B12 deficiency may occur with long-term metformin use.

Do not take Sita M ER 50/1000 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk),iodinated contrast media,carbonic anhydrase inhibitors (e.g. topiramate, acetazolamide),cimetidine and other cationic drugs affecting renal tubular secretion,insulin/sulfonylureas (increased hypoglycemia risk),diuretics and ACE inhibitors/ARBs (may affect renal function),digoxin (may increase levels with sitagliptin)

How to store Sita M ER 50/1000 Tablet

Store at room temperature (below 25°C), protect from moisture and direct light, keep in original pack, keep out of reach of children.

Expert advice for Sita M ER 50/1000 Tablet

Take Sita OD MSR 50/500 Tablet ER with food to lower your chance of having an upset stomach. Take it in addition to regular exercise and a healthy diet to lower blood sugar levels. The chances of weight gain and low blood sugar are lower than with other diabetes medicines. Monitor your blood sugar level regularly while you are taking this medicine. Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic. Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain, as Sita OD MSR 50/500 Tablet ER may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Manufacturer and class

Manufacturer:

MSN LABORATORIES

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide (metformin)