
Actibile 150MG Tab
Zydus Healthcare Pharma - Tablet - 150 mg - 10 S
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Methylcobalamin (750mcg) + Metformin (1gm)
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Sugamet Mc 1000 is used for sugamet MC 1000 Tablet SR is used in the treatment of type 2 diabetes.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Sugamet Mc 1000 contains Methylcobalamin (750mcg) + Metformin (1gm). It belongs to the B-complex vitamin and Biguanide class of medicines.
Sugamet MC 1000 Tablet SR is used in the treatment of type 2 diabetes.
Sugamet MC 1000 Tablet SR is a combination of two medicines: Metformin and methylcobalamin which treat diabetes. Metformin is a biguanide which decreases the production and absorption of sugar in your body, and allows better use of existing insulin. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sugamet MC 1000 Tablet SR is to be taken with food.<br>Sugamet MC 1000 Tablet SR may cause stomach upset if taken on empty stomach.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine is unlikely to cause serious harm, because the body passes surplus B vitamins out in the urine. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Sugamet Mc are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Sugamet MC 1000 Tablet SR may be unsafe to use during pregnancy.<br>Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. |
|---|---|
| Breastfeeding | Sugamet MC 1000 Tablet SR is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby. |
| Alcohol | Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms. |
| Driving | Not expected to affect your ability to drive. |
| Kidney | Sugamet MC 1000 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Sugamet MC 1000 Tablet SR may be needed. Please consult your doctor.<br>Use of Sugamet MC 1000 Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine. |
| Liver | Sugamet MC 1000 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Sugamet MC 1000 Tablet SR may be needed. Please consult your doctor.<br>Sugamet MC 1000 Tablet SR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease. |
| Habit forming | No |
Tingling, numbness or burning in the hands and feet should be assessed by a doctor rather than self-treated — a supplement does not address the cause. Folic acid can mask a vitamin B12 deficiency while nerve damage continues, so B12 should be checked before taking folic acid long term. Bright yellow urine after a B-complex dose is expected and harmless. Stomach upset is common in the first two weeks and usually settles; taking it with food helps. Tell your doctor before any surgery or a scan that uses contrast dye — this medicine is usually stopped for a short time around them. Stop and seek urgent care if you develop deep rapid breathing, severe weakness, muscle pain or vomiting with cold clammy skin. This is rare but serious. Long-term use can lower vitamin B12, so your doctor may check it from time to time.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Long-term metformin, acid-reducing medicines and some anti-epileptics lower B12 or folate levels. Tell your doctor if you take levodopa, as vitamin B6 can reduce its effect. Tell your doctor about water tablets, steroids, and any contrast dye scan. Alcohol increases the risk of the rare acid build-up and should be limited.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
A supplement corrects a deficiency; it is not a general energy tonic. If you are on it for nerve symptoms, keep your review appointment so the underlying cause is looked for. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

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The information on Sugamet Mc 1000 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.