
Acetamide 250
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Metformin (1000mg) + Pioglitazone (15mg) + Teneligliptin (20mg)
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Tenepride Pm 1000 is used for treatment of Type 2 diabetes mellitus.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Tenepride Pm 1000 contains Metformin (1000mg) + Pioglitazone (15mg) + Teneligliptin (20mg). It belongs to the Biguanide, Oral anti-diabetic and DPP-4 inhibitor class of medicines.
Treatment of Type 2 diabetes mellitus
Tenepride PM 1000mg/15mg/20mg Tablet is a combination of three antidiabetic medications: metformin, pioglitazone, and teneligliptin. Metformin decreases the amount of glucose absorbed from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Pioglitazone primarily acts on muscle, fat, and liver cells to enhance their insulin response, making it easier for these cells to take up glucose from the bloodstream. It also reduces the production of glucose by the liver, which is a common problem in people with type 2 diabetes. Teneligliptin increases the release of insulin from the pancreas and decreases the hormone (glucagon) that raises blood sugar levels. This reduces fasting and post-meal sugar levels.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tenepride PM 1000mg/15mg/20mg Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Tenepride PM 1000mg/15mg/20mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar and marked stomach upset. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Tenepride Pm are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding SAFE IF PRESCRIBED |
| Alcohol | Alcohol UNSAFE |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver UNSAFE |
| Habit forming | No |
Stomach upset is common in the first two weeks and usually settles; taking it with food helps. Tell your doctor before any surgery or a scan that uses contrast dye — this medicine is usually stopped for a short time around them. Stop and seek urgent care if you develop deep rapid breathing, severe weakness, muscle pain or vomiting with cold clammy skin. This is rare but serious. Long-term use can lower vitamin B12, so your doctor may check it from time to time. If you feel shaky, sweaty, confused or unusually hungry, take sugar, glucose or a sweet drink at once and tell your doctor — these are signs your blood sugar has fallen too low. If a low-sugar episode happens while on an alpha-glucosidase inhibitor such as voglibose or acarbose, use glucose — ordinary sugar and sweets work more slowly. Tell your doctor about any new swelling of the ankles, breathlessness or sudden weight gain. Stop and see a doctor urgently if you get severe, persistent abdominal pain that spreads to your back, with or without vomiting. Tell your doctor if you develop severe or disabling joint pain. Blisters or peeling of the skin should be reported promptly.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine.
Tell your doctor about water tablets, steroids, and any contrast dye scan. Alcohol increases the risk of the rare acid build-up and should be limited. Low blood sugar is more likely when combined with insulin or a sulfonylurea. Low blood sugar is more likely when this is combined with a sulfonylurea or insulin; your doctor may lower that dose.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Follow the recommended dosage and timing. Do not make any changes to your medication regimen without consulting your doctor first. Regularly monitor your blood sugar levels as recommended by your doctor. Learn to recognize the symptoms of hypoglycemia (low blood sugar) and how to respond. Tenepride PM 1000mg/15mg/20mg Tablet can lower blood sugar levels, and it's important to be prepared to treat low blood sugar if it occurs. Always carry sugary candies with you. Complement your medication with a healthy lifestyle. This includes a balanced diet, regular physical activity, maintaining a healthy weight, and avoiding excessive alcohol consumption. Continue with regular follow-up appointments with your doctor.

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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.