Glimibrit M 1 Tablet

Composition

Glimepiride (1mg) + Metformin (500mg)

Uses of Glimibrit M 1 Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone are insufficient; useful when fasting and post-meal glucose are both elevated requiring dual therapy.

How it works

Glimepiride closes pancreatic β-cell ATP-sensitive K+ channels (SUR1/Kir6.2), causing depolarisation, Ca2+ influx and insulin release; metformin activates AMPK to reduce hepatic gluconeogenesis and improve peripheral insulin sensitivity.

Directions for use

Take Glimibrit M 1 Tablet with the first main meal of the day to reduce hypoglycaemia and GI upset; swallow whole with water; dose titration must be done by physician based on glucose readings.

Side effects

Common side effects of Glimibrit M 1 Tablet may include:

• •Common: hypoglycaemia
• •nausea
• •diarrhoea
• •metallic taste
• •weight gain
• •headache; Serious: lactic acidosis (metformin)
• •severe/prolonged hypoglycaemia
• •cholestatic jaundice

Warnings & precautions

Monitor renal function before and during therapy; stop and seek urgent care for rapid breathing, severe weakness, abdominal pain (lactic acidosis symptoms); counsel on hypoglycaemia recognition and carrying glucose; dose reduction needed in elderly or reduced renal function; avoid dehydration and prolonged fasting; use caution in G6PD deficiency (haemolysis risk with sulfonylureas).