Glimibrit M 1 Tablet

Composition of Glimibrit M 1 Tablet

Glimibrit M 1 Tablet contains Glimepiride (1mg) + Metformin (500mg). It belongs to the Sulfonylurea and Biguanide class of medicines.

Uses of Glimibrit M 1 Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone are insufficient; useful when fasting and post-meal glucose are both elevated requiring dual therapy.

Key benefits

• Lowers blood sugar quickly
• Long-established and inexpensive
• First-choice medicine for type 2 diabetes
• Does not usually cause weight gain
• Low risk of hypoglycaemia when used alone

How Glimibrit M 1 Tablet works

Glimepiride closes pancreatic β-cell ATP-sensitive K+ channels (SUR1/Kir6.2), causing depolarisation, Ca2+ influx and insulin release; metformin activates AMPK to reduce hepatic gluconeogenesis and improve peripheral insulin sensitivity.

How to take Glimibrit M 1 Tablet

Take Glimibrit M 1 Tablet with the first main meal of the day to reduce hypoglycaemia and GI upset; swallow whole with water; dose titration must be done by physician based on glucose readings.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Glimibrit M 1 Tablet

Most side effects of Glimibrit M are mild and settle as the body adjusts. Reported side effects include:

• Common: hypoglycaemia
• nausea
• diarrhoea
• metallic taste
• weight gain
• headache; Serious: lactic acidosis (metformin)
• severe/prolonged hypoglycaemia
• cholestatic jaundice
• blood dyscrasias.

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Glimibrit M 1 Tablet

Warnings and precautions

Monitor renal function before and during therapy; stop and seek urgent care for rapid breathing, severe weakness, abdominal pain (lactic acidosis symptoms); counsel on hypoglycaemia recognition and carrying glucose; dose reduction needed in elderly or reduced renal function; avoid dehydration and prolonged fasting; use caution in G6PD deficiency (haemolysis risk with sulfonylureas).

Do not take Glimibrit M if

Type 1 diabetes; diabetic ketoacidosis; severe renal impairment (eGFR <30 mL/min/1.73m²) or acute kidney injury; severe hepatic impairment; history of lactic acidosis; sulfonylurea allergy; pregnancy/breastfeeding unless specifically advised.

Interactions with other medicines

Alcohol: increases hypoglycaemia and lactic acidosis risk; iodinated contrast media: precipitates metformin-associated lactic acidosis—hold metformin at/around procedure per protocol; beta-blockers (propranolol/metoprolol): mask hypoglycaemia symptoms; fluoroquinolones (levofloxacin): dysglycaemia; ACE inhibitors: may enhance glucose-lowering effect; sulfonamides/azoles: increase sulfonylurea levels via CYP inhibition.

How to store Glimibrit M 1 Tablet

Store at 20–25°C (permitted 15–30°C) in a dry place, protected from moisture and direct light; keep in original blister.

Expert advice for Glimibrit M 1 Tablet

<div class="style__desktop-container___1hcBT"><div class="style__desktop-video___2GTR9"><div class="styles__video-img___1rCzR"><div class=""/><div class=""/></div></div><div><div><div><div><div class="ExpertAdviceItem__content___1Djk2"><ul><li><div>You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.</div></li> <li>You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Glimibrit M 1 Tablet PR.</li> <li>Take it with food to lower your chance of having an upset stomach.</li> <li>Monitor your blood sugar level regularly while you are taking this medicine. </li> <li>Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.</li> <li>It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. </li> <li>Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glimibrit M 1 Tablet PR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.</li> <li>Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).</li></ul></div></div></div></div></div></div>

Manufacturer and class

Manufacturer:

ELBRIT LIFE SCIENCES PVT LTD

Therapeutic class:

Sulfonylurea And Biguanide

Drug class:

Sulfonylurea and Biguanide