Bitaglip M 500 Tablet

Composition of Bitaglip M 500 Tablet

Bitaglip M 500 Tablet contains Sitagliptin 50 mg + Metformin 500 mg (as Metformin Hydrochloride). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Bitaglip M 500 Tablet

• Type 2 diabetes mellitus: to improve blood glucose control along with diet and exercise
• when dual therapy is appropriate

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin response in a glucose-dependent manner
• Reduces hepatic glucose production
• Helps improve overall HbA1c control
• Weight-neutral option compared with some antidiabetics

How Bitaglip M 500 Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones, enhancing glucose-dependent insulin release and reducing glucagon secretion. Metformin decreases hepatic glucose production and improves insulin sensitivity, lowering intestinal glucose absorption.

How to take Bitaglip M 500 Tablet

Oral tablet. Usually taken with meals to reduce stomach upset; swallow whole with water. Dose and frequency as prescribed by the doctor; do not crush/chew. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Bitaglip M 500 Tablet

Most side effects of Bitaglip M are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• upper respiratory tract infection

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Bitaglip M 500 Tablet

Warnings and precautions

Risk of lactic acidosis with metformin (seek urgent care for rapid breathing, severe weakness, muscle pain, unusual sleepiness). Use with caution in kidney or liver impairment; dose adjustment/avoid in low eGFR as advised by physician. Temporarily stop before/after iodinated contrast studies or major surgery as directed. Pancreatitis risk with sitagliptin (severe persistent abdominal pain); severe joint pain and hypersensitivity reactions can occur. Monitor vitamin B12 with long-term metformin use. Avoid in type 1 diabetes or diabetic ketoacidosis.

Do not take Bitaglip M if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cimetidine, digoxin, insulin or sulfonylureas (increased hypoglycaemia risk), ACE inhibitors/ARBs and diuretics (may affect kidney function)

How to store Bitaglip M 500 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

Expert advice for Bitaglip M 500 Tablet

It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

R.B.PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide