Carivalan 12.5/5 Tablet

Composition of Carivalan 12.5/5 Tablet

Carivalan 12.5/5 Tablet contains Carvedilol 12.5 mg + Ivabradine 5 mg (tablet). It belongs to the Beta-blocker with alpha-1 blocker (carvedilol) + If channel inhibitor (ivabradine) class of medicines.

Uses of Carivalan 12.5/5 Tablet

• Chronic heart failure (stable) and chronic stable angina in patients where heart rate control is needed; used to reduce heart rate
• improve symptoms and exercise tolerance
• and reduce risk of worsening heart failure as prescribed.

Key benefits

• Lowers heart rate
• Reduces angina symptoms
• Improves heart failure symptoms
• Decreases cardiac workload
• Helps improve exercise tolerance

How Carivalan 12.5/5 Tablet works

Carvedilol is a non-selective beta-blocker with alpha-1 blocking action that slows the heart rate and lowers blood pressure, reducing cardiac workload. Ivabradine selectively inhibits the If current in the sinoatrial node, lowering heart rate without reducing contractility. Together they improve heart efficiency and symptom control in selected patients.

How to take Carivalan 12.5/5 Tablet

Take by mouth exactly as prescribed. Usually taken twice daily with food (carvedilol is best taken with meals to reduce dizziness); swallow whole with water. Do not stop suddenly; dose is typically titrated based on heart rate and blood pressure.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause a dangerously slow heartbeat, a severe fall in blood pressure, wheezing and fits. It can seriously disturb the heart's rhythm and blood pressure. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Carivalan 12.5/5 Tablet

Most side effects of Carivalan 12.5/5 are mild and settle as the body adjusts. Reported side effects include:

• Dizziness
• fatigue
• low blood pressure
• slow heart rate (bradycardia)
• headache
• nausea
• visual brightness/photopsia
• shortness of breath
• swelling (edema)

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Carivalan 12.5/5 Tablet

Warnings and precautions

Prescription-only. Can cause excessive slowing of heart rate, low blood pressure, worsening heart failure during initiation/titration, and dizziness/fainting—monitor BP and pulse. Not recommended in severe bradycardia, sick sinus syndrome/AV block without pacemaker, acute decompensated heart failure, severe hypotension, severe hepatic impairment, or cardiogenic shock. Use caution in asthma/COPD, diabetes (may mask hypoglycemia), peripheral vascular disease, thyroid disorders, and in elderly. Do not stop abruptly (risk of angina/arrhythmia). Seek urgent care for fainting, very slow pulse, severe breathlessness, or chest pain.

Do not take Carivalan 12.5/5 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with a very slow heart rate, certain heart block disorders, or uncontrolled heart failure. Generally avoided in severe asthma. Your doctor will check that this is suitable for your particular heart condition.

Interactions with other medicines

Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, telithromycin, ritonavir) and non-dihydropyridine calcium channel blockers (verapamil, diltiazem) increase ivabradine levels and bradycardia risk; other heart-rate-lowering drugs (digoxin, amiodarone, beta-blockers) increase bradycardia/AV block risk; antihypertensives and nitrates increase hypotension risk; CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John’s wort) may reduce ivabradine effect; insulin/oral antidiabetics—monitor glucose; clonidine—withdrawal interactions; NSAIDs may reduce antihypertensive effect.

How to store Carivalan 12.5/5 Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Carivalan 12.5/5 Tablet

Take it at the same time each day and do not miss doses. Learn to check your own pulse, and report a persistently slow one. Keep an up-to-date list of your medicines with you.

Manufacturer and class

Manufacturer:

SERDIA PHARMACEUTICALS`

Therapeutic class:

Cardiovascular (Antianginal/Heart failure therapy)

Drug class:

Beta-blocker with alpha-1 blocker (carvedilol) + If channel inhibitor (ivabradine)