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Alkem Lab - Tablet - 15 S
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Chlorthalidone + Cilnidipine
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Cilnikem Ct 12.5 is used for this medicine is used in the treatment of high blood pressure, heart failure, fluid retention and angina.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Cilnikem Ct 12.5 contains Chlorthalidone + Cilnidipine. It belongs to the Water tablet and Calcium channel blocker class of medicines.
This medicine combines 2 active ingredients: Chlorthalidone and Cilnidipine. Chlorthalidone helps your kidneys remove surplus salt and water, which reduces swelling and lowers blood pressure. Cilnidipine relaxes the muscle in the walls of your blood vessels so they widen, which lowers blood pressure and eases the work of the heart.
Use this medicine as your doctor has directed. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe dehydration, a sharp fall in blood pressure and dangerous salt imbalances. It can cause a severe fall in blood pressure and a dangerously slow or irregular heartbeat. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Cilnikem Ct are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Consult your doctor before using this in pregnancy. |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Alcohol may worsen the side effects of this medicine. Limit it. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Take it in the morning so that passing urine does not disturb your sleep. Your doctor will check your salts and kidney function with blood tests — do not skip them. Report muscle cramps, marked weakness, confusion or an irregular heartbeat; these can be signs your potassium or sodium has fallen. In hot weather or during an illness with vomiting or loose motions, tell your doctor — you may become dehydrated quickly. Ankle swelling is the commonest reason people stop this medicine — tell your doctor, as there are ways to manage it. Tell your doctor if your chest pain becomes more frequent or more severe after starting. Swollen, tender or overgrown gums should be reported; good brushing and regular dental care reduce the risk.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people who are unable to pass urine, or who are severely dehydrated. Not for people with very low blood pressure or with severe narrowing of the aortic valve.
Anti-inflammatory painkillers blunt the effect and can strain the kidneys. Lithium and digoxin levels are affected; tell your doctor if you take either. Potassium-sparing types must not be combined with potassium supplements without supervision. Grapefruit juice raises the level of some of these medicines in the blood — avoid it. Tell your doctor about other blood pressure medicines, and about simvastatin in particular.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Weigh yourself at the same time each day if you have heart failure, and report a rapid gain. Do not add extra salt, and ask before using a potassium-based salt substitute. Raising your legs when sitting, and reducing salt, helps with ankle swelling. Do not stop suddenly without asking your doctor.

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The information on Cilnikem Ct 12.5 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.