Coralan 7.5 Tablet

Composition of Coralan 7.5 Tablet

Coralan 7.5 Tablet contains Ivabradine 7.5 mg. It belongs to the If channel inhibitor (heart rate lowering agent) class of medicines.

Uses of Coralan 7.5 Tablet

• Chronic stable angina
• Chronic heart failure (with reduced ejection fraction) in eligible patients to reduce heart rate

Key benefits

• Reduces heart rate
• Improves angina symptoms and exercise tolerance
• Helps control heart rate in eligible heart failure patients
• May reduce hospitalizations for worsening heart failure in selected patients

How Coralan 7.5 Tablet works

Ivabradine selectively inhibits the If (funny) current in the sinoatrial node. This slows the heart rate without reducing contractility or blood pressure significantly. Lower heart rate reduces myocardial oxygen demand and improves symptoms in suitable patients.

How to take Coralan 7.5 Tablet

Take exactly as prescribed, usually twice daily with meals. Swallow whole with water at the same times each day. Do not stop abruptly without medical advice; monitor pulse and blood pressure as advised.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can seriously disturb the heart's rhythm and blood pressure. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Coralan 7.5 Tablet

Most side effects of Coralan are mild and settle as the body adjusts. Reported side effects include:

• Bradycardia
• visual phenomena (phosphenes/brightness)
• headache
• dizziness
• fatigue
• atrial fibrillation
• hypotension

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Coralan 7.5 Tablet

Warnings and precautions

Not for acute heart failure, cardiogenic shock, severe hypotension, sick sinus syndrome/SA block, pacemaker dependence, severe hepatic impairment, resting heart rate very low, or in combination with strong CYP3A4 inhibitors. Use caution in conduction disorders and in patients prone to atrial fibrillation; report palpitations or irregular heartbeat. Can cause temporary visual disturbances; caution while driving at night.

Do not take Coralan if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will check that this is suitable for your particular heart condition.

Interactions with other medicines

Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, erythromycin, ritonavir), CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John"s wort), other heart rate lowering drugs (beta-blockers, diltiazem, verapamil, digoxin, amiodarone), grapefruit juice

How to store Coralan 7.5 Tablet

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for Coralan 7.5 Tablet

Take it at the same time each day and do not miss doses. Keep an up-to-date list of your medicines with you.

Manufacturer and class

Manufacturer:

SERDIA PHARMACEUTICALS`

Therapeutic class:

Cardiac (antianginal/heart failure adjunct)

Drug class:

If channel inhibitor (heart rate lowering agent)