Gemerdapa XR 10/2/500

Composition of Gemerdapa XR 10/2/500

Gemerdapa XR 10/2/500 contains Dapagliflozin 10 mg + Glimepiride 2 mg + Metformin Hydrochloride 500 mg (Extended Release). It belongs to the SGLT2 inhibitor + Sulfonylurea + Biguanide (extended-release metformin) class of medicines.

Uses of Gemerdapa XR 10/2/500

• Type 2 diabetes mellitus: to improve blood sugar control in adults
• as an adjunct to diet and exercise
• when combination therapy is appropriate.

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves long-term glycaemic control (HbA1c)
• Helps reduce insulin resistance
• Promotes urinary glucose excretion which may aid weight reduction
• Convenient once-daily extended-release metformin regimen

How Gemerdapa XR 10/2/500 works

Dapagliflozin (SGLT2 inhibitor) lowers blood glucose by increasing urinary glucose excretion via the kidneys. Metformin (biguanide) reduces hepatic glucose production and improves insulin sensitivity. Glimepiride (sulfonylurea) increases insulin release from pancreatic beta cells.

How to take Gemerdapa XR 10/2/500

Oral tablet (XR). Take exactly as prescribed, usually once daily with food (preferably with the evening meal) to reduce stomach upset and lower hypoglycaemia risk. Swallow whole; do not crush, break, or chew. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause dehydration and a fall in blood pressure. It can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Gemerdapa XR 10/2/500

Most side effects of Gemerdapa XR 10/2/500 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• dizziness
• headache
• nausea
• diarrhoea
• abdominal discomfort
• decreased appetite
• increased urination
• urinary tract infection
• genital fungal infection
• dehydration
• weakness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Gemerdapa XR 10/2/500

Warnings and precautions

Risk of hypoglycaemia (higher with sulfonylurea), especially with missed meals/exercise/alcohol; monitor sugars. Metformin may rarely cause lactic acidosis—higher risk in kidney impairment, dehydration, severe infection, shock, liver disease, or heavy alcohol use; stop and seek care if rapid breathing, severe weakness, drowsiness occur. Dapagliflozin can cause genital infections, UTIs, volume depletion/low BP and may precipitate ketoacidosis (sometimes with near-normal sugars); seek urgent care for nausea/vomiting, abdominal pain, fast breathing. Kidney function should be assessed before and during treatment; not recommended in severe renal impairment. Temporarily withhold around major surgery or during acute illness/poor intake and before iodinated contrast procedures as advised by doctor.

Do not take Gemerdapa XR 10/2/500 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Insulin/other antidiabetics (increased hypoglycaemia), diuretics (increased dehydration/low BP), ACE inhibitors/ARBs (may enhance BP lowering), corticosteroids and sympathomimetics (raise glucose), beta-blockers (mask hypoglycaemia symptoms), rifampicin/phenytoin/other enzyme inducers (may reduce sulfonylurea effect), azole antifungals/macrolides (may increase sulfonylurea effect), alcohol (increases hypoglycaemia and lactic acidosis risk), iodinated contrast media (risk of lactic acidosis—hold metformin as directed)

How to store Gemerdapa XR 10/2/500

Store at room temperature (below 25°C), protected from moisture and direct light. Keep in original blister pack and out of reach of children.

Expert advice for Gemerdapa XR 10/2/500

Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine. Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

SUN PHARMA

Therapeutic class:

Antidiabetic

Drug class:

SGLT2 inhibitor + Sulfonylurea + Biguanide (extended-release metformin)