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Prescription requiredSun PharmaAnti-diabetic
Istamet Empa 25/100/1000 mg Tablet
Empagliflozin + Metformin + Sitagliptin
₹205MRP ₹2165% offIn stock
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Istamet Empa 25/100/1000 mg Tablet is used for this medicine is used in the treatment of type 2 diabetes, heart failure and chronic kidney disease.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Empagliflozin + Metformin + Sitagliptin
Available variants: tablet 1000mg 10`S
Best price: ₹205 (₹20.48 per tablet)
MRP: ₹216
Prescription: Required
Manufacturer: SUN PHARMA 2
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Composition of Istamet Empa 25/100/1000 mg Tablet
Istamet Empa 25/100/1000 mg Tablet contains Empagliflozin + Metformin + Sitagliptin. It belongs to the SGLT2 inhibitor / GLP-1 analogue, Biguanide and DPP-4 inhibitor class of medicines.
Uses of Istamet Empa 25/100/1000 mg Tablet
- This medicine is used in the treatment of type 2 diabetes
- heart failure and chronic kidney disease.
Key benefits
- Protects the heart and kidneys as well as lowering sugar
- Usually causes modest weight loss
- Low risk of hypoglycaemia when used alone
- First-choice medicine for type 2 diabetes
- Does not usually cause weight gain
- Weight neutral
- Usually taken once a day
How Istamet Empa 25/100/1000 mg Tablet works
This medicine combines 3 active ingredients: Empagliflozin, Metformin and Sitagliptin. Empagliflozin lowers blood sugar by making your kidneys pass surplus glucose out in the urine, and also eases the load on the heart and kidneys. Metformin lowers blood sugar by reducing the amount of glucose your liver releases and by helping your muscles respond better to your own insulin. It does not force your pancreas to make more insulin, which is why it rarely causes low blood sugar on its own. Sitagliptin lowers blood sugar by protecting the natural gut hormones that tell your pancreas to release insulin after a meal, so the effect is strongest when your sugar is highest.
How to take Istamet Empa 25/100/1000 mg Tablet
Swallow the tablet whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it in the morning, with or without food. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine can cause dehydration and a fall in blood pressure. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Istamet Empa 25/100/1000 mg Tablet
Most side effects of Istamet Empa 25/100/1000 mg are mild and settle as the body adjusts. Reported side effects include:
- Passing urine more often
- Thirst
- Genital itching or thrush
- Urinary infection
- Nausea
- Loose motions
- Stomach pain
- Metallic taste
- Loss of appetite
- Flatulence
- Headache
- Sore throat
- Blocked or runny nose
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Istamet Empa 25/100/1000 mg Tablet
| Pregnancy | Not recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant. |
|---|---|
| Breastfeeding | Not recommended while breastfeeding. |
| Alcohol | Do not drink alcohol while taking this medicine. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Warnings and precautions
Drink enough water, especially in hot weather or if you have loose motions — this medicine makes you pass more urine. Seek urgent care for nausea with vomiting, stomach pain and deep rapid breathing, even if your sugar reading is normal. Report any pain, tenderness, redness or swelling in the genital area or perineum immediately — this is rare but needs same-day attention. Genital thrush is common; keep the area clean and dry and tell your doctor if it recurs. Stomach upset is common in the first two weeks and usually settles; taking it with food helps. Tell your doctor before any surgery or a scan that uses contrast dye — this medicine is usually stopped for a short time around them. Stop and seek urgent care if you develop deep rapid breathing, severe weakness, muscle pain or vomiting with cold clammy skin. This is rare but serious. Long-term use can lower vitamin B12, so your doctor may check it from time to time. Stop and see a doctor urgently if you get severe, persistent abdominal pain that spreads to your back, with or without vomiting. Tell your doctor if you develop severe or disabling joint pain. Blisters or peeling of the skin should be reported promptly.
Do not take Istamet Empa 25/100/1000 mg if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Interactions with other medicines
Water tablets increase the risk of dehydration and low blood pressure when taken with this. Low blood sugar is more likely when combined with insulin or a sulfonylurea. Tell your doctor about water tablets, steroids, and any contrast dye scan. Alcohol increases the risk of the rare acid build-up and should be limited. Low blood sugar is more likely when this is combined with a sulfonylurea or insulin; your doctor may lower that dose.
How to store Istamet Empa 25/100/1000 mg Tablet
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Expert advice for Istamet Empa 25/100/1000 mg Tablet
Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them. It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them.
Manufacturer and class
- Manufacturer:
- SUN PHARMA 2
- Therapeutic class:
- Anti-diabetic
- Drug class:
- SGLT2 inhibitor / GLP-1 analogue, Biguanide and DPP-4 inhibitor
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Istamet Empa 25/100/1000 mg Tablet FAQs
What is Istamet Empa 25/100/1000 mg Tablet used for?
Istamet Empa 25/100/1000 mg Tablet is commonly used for This medicine is used in the treatment of type 2 diabetes, heart failure and chronic kidney disease. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Istamet Empa 25/100/1000 mg Tablet?
Istamet Empa 25/100/1000 mg Tablet contains Empagliflozin + Metformin + Sitagliptin. If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Istamet Empa 25/100/1000 mg Tablet?
Swallow the tablet whole with a glass of water. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Istamet Empa 25/100/1000 mg Tablet work?
This medicine combines 3 active ingredients: Empagliflozin, Metformin and Sitagliptin.
Is Istamet Empa 25/100/1000 mg Tablet a prescription medicine?
Yes. Istamet Empa 25/100/1000 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Istamet Empa 25/100/1000 mg Tablet?
The side effects reported most often with Istamet Empa 25/100/1000 mg are Passing urine more often, Thirst, Genital itching or thrush, Urinary infection, Nausea. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Istamet Empa 25/100/1000 mg Tablet be taken during pregnancy?
Not recommended in pregnancy — it may harm the developing baby. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Istamet Empa 25/100/1000 mg.
Can I drink alcohol while taking Istamet Empa 25/100/1000 mg Tablet?
Do not drink alcohol while taking this medicine.
What if I miss a dose of Istamet Empa 25/100/1000 mg Tablet?
Take it as soon as you remember.
Is Istamet Empa 25/100/1000 mg Tablet habit forming?
No. Istamet Empa 25/100/1000 mg Tablet is not known to be habit forming when taken as prescribed.
How much does Istamet Empa 25/100/1000 mg Tablet cost on PingMeDoc Pharmacy?
Istamet Empa 25/100/1000 mg Tablet starts at ₹205 (MRP ₹216) on PingMeDoc Pharmacy. Available in tablet 1000mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Istamet Empa 25/100/1000 mg Tablet?
Istamet Empa 25/100/1000 mg Tablet is manufactured by SUN PHARMA 2. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Istamet Empa 25/100/1000 mg Tablet delivered?
Istamet Empa 25/100/1000 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Istamet Empa 25/100/1000 mg Tablet, Quick facts
- Salt
- Empagliflozin + Metformin + Sitagliptin
- Form
- tablet
- Best price
- ₹205 (₹20.48 per tablet)
- MRP
- ₹216
- Prescription
- Required (Rx)
- Brand
- SUN PHARMA 2
- Manufacturer
- SUN PHARMA 2
- Therapeutic class
- Anti-diabetic
- Drug class
- SGLT2 inhibitor / GLP-1 analogue, Biguanide and DPP-4 inhibitor
- Habit forming
- No
- Variants
- tablet 1000mg 10`S
- Delivery
- Standard across India
References
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.
- PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
- CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Istamet Empa 25/100/1000 mg Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.