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OTC · No prescriptionProcter & Gamble Health LtdVitamin and mineral supplement and Vitamin supplement

Osto-Polybion Syrup

Vitamin D3 (200IU/5ml) + Cyanocobalamin (2.5mcg/5ml) + Calcium (210mg/5ml)

Osto-Polybion Syrup is used for this medicine is used in the treatment of vitamin d deficiency, low calcium, osteoporosis, bone health, vitamin b deficiency, nerve pain and tingling, anaemia and tiredness due to deficiency.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

₹277₹0.92 per ml
Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Vitamin D3 (200IU/5ml) + Cyanocobalamin (2.5mcg/5ml) + Calcium (210mg/5ml)
Available variants: syrup syrup 300ML
Best price: ₹277 (₹0.92 per ml)
Prescription: Not required
Manufacturer: P&G

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Osto-Polybion Syrup

Osto-Polybion Syrup contains Vitamin D3 (200IU/5ml) + Cyanocobalamin (2.5mcg/5ml) + Calcium (210mg/5ml). It belongs to the Vitamin D / calcium supplement and B-complex vitamin class of medicines.

Uses of Osto-Polybion Syrup

  • This medicine is used in the treatment of vitamin d deficiency
  • low calcium
  • osteoporosis
  • bone health
  • vitamin b deficiency
  • nerve pain and tingling
  • anaemia and tiredness due to deficiency.

Key benefits

  • Corrects a very common deficiency in India
  • Supports bone strength and muscle function
  • Reduces the risk of fractures when a deficiency is present
  • Corrects a deficiency that causes tiredness and nerve symptoms
  • Supports the formation of healthy red blood cells
  • Generally well tolerated

How Osto-Polybion Syrup works

This medicine combines 3 active ingredients: Vitamin d, Methylcobalamin and Calcium. Vitamin d helps your gut absorb calcium and keeps the mineral level in your blood and bones where it should be. Methylcobalamin replaces a B vitamin your body needs to make red blood cells, to keep nerves healthy and to release energy from food. Calcium helps your gut absorb calcium and keeps the mineral level in your blood and bones where it should be.

How to take Osto-Polybion Syrup

Shake the bottle well before each dose and measure it with the cup, spoon or dropper supplied — a kitchen spoon is not an accurate measure. Take it with food. Follow the dose and the duration written on your prescription.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can raise blood calcium dangerously, causing thirst, frequent urination, vomiting, confusion and kidney damage. It is unlikely to cause serious harm, because the body passes surplus B vitamins out in the urine. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Osto-Polybion Syrup

Most side effects of Osto-Polybion are mild and settle as the body adjusts. Reported side effects include:

  • Constipation
  • Bloating
  • Nausea
  • Stomach discomfort
  • Stomach upset
  • Harmless bright yellow urine
  • Loose motions

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Osto-Polybion Syrup

PregnancyGenerally considered safe in pregnancy. Tell your doctor if you are pregnant or planning to be.
BreastfeedingGenerally considered safe while breastfeeding.
AlcoholAlcohol may worsen the side effects of this medicine. Limit it.
DrivingNot expected to affect your ability to drive.
KidneyConsult your doctor if you have kidney disease.
LiverNo dose change is usually needed in liver disease.
Habit formingNo

Warnings and precautions

Do not take more than your doctor has advised. Vitamin D builds up in the body and too much raises blood calcium, causing thirst, frequent urination, nausea and confusion. High-dose weekly or monthly sachets are prescription strengths — do not repeat one because you missed a week. Tell your doctor if you have had kidney stones or have kidney disease. Tingling, numbness or burning in the hands and feet should be assessed by a doctor rather than self-treated — a supplement does not address the cause. Folic acid can mask a vitamin B12 deficiency while nerve damage continues, so B12 should be checked before taking folic acid long term. Bright yellow urine after a B-complex dose is expected and harmless.

Do not take Osto-Polybion if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with a high blood calcium level, or with certain kidney stones.

Interactions with other medicines

Calcium reduces the absorption of thyroid tablets, several antibiotics and iron — separate them by a few hours. Water tablets of the thiazide group raise calcium further when combined. Long-term metformin, acid-reducing medicines and some anti-epileptics lower B12 or folate levels. Tell your doctor if you take levodopa, as vitamin B6 can reduce its effect.

How to store Osto-Polybion Syrup

Store below 30°C, away from direct sunlight. Do not freeze. Once opened, use it within the period printed on the pack. Keep out of the reach of children.

Expert advice for Osto-Polybion Syrup

Take calcium with food, and split the day's total if you take a large amount. Sunlight helps your body make its own vitamin D. Have your level rechecked as your doctor advises rather than continuing high doses indefinitely. A supplement corrects a deficiency; it is not a general energy tonic. If you are on it for nerve symptoms, keep your review appointment so the underlying cause is looked for.

Manufacturer and class

Manufacturer:
P&G
Therapeutic class:
Vitamin and mineral supplement and Vitamin supplement
Drug class:
Vitamin D / calcium supplement and B-complex vitamin

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Osto-Polybion Syrup FAQs

What is Osto-Polybion Syrup used for?
Osto-Polybion Syrup is commonly used for This medicine is used in the treatment of vitamin d deficiency, low calcium, osteoporosis, bone health, vitamin b deficiency, nerve pain and tingling, anaemia and tiredness due to deficiency. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Osto-Polybion Syrup?
Osto-Polybion Syrup contains Vitamin D3 (200IU/5ml) + Cyanocobalamin (2.5mcg/5ml) + Calcium (210mg/5ml). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Osto-Polybion Syrup?
Shake the bottle well before each dose and measure it with the cup, spoon or dropper supplied — a kitchen spoon is not an accurate measure. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Osto-Polybion Syrup work?
This medicine combines 3 active ingredients: Vitamin d, Methylcobalamin and Calcium.
Is Osto-Polybion Syrup a prescription medicine?
No. Osto-Polybion Syrup is available over the counter (OTC), no prescription is required. However, it is always safer to consult a doctor or pharmacist before use.
What are the common side effects of Osto-Polybion Syrup?
The side effects reported most often with Osto-Polybion are Constipation, Bloating, Nausea, Stomach discomfort, Stomach upset. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Osto-Polybion Syrup be taken during pregnancy?
Generally considered safe in pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Osto-Polybion.
Can I drink alcohol while taking Osto-Polybion Syrup?
Alcohol may worsen the side effects of this medicine.
What if I miss a dose of Osto-Polybion Syrup?
Take it as soon as you remember.
Is Osto-Polybion Syrup habit forming?
No. Osto-Polybion Syrup is not known to be habit forming when taken as prescribed.
How much does Osto-Polybion Syrup cost on PingMeDoc Pharmacy?
Osto-Polybion Syrup starts at ₹277 on PingMeDoc Pharmacy. Available in syrup syrup 300ML. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Osto-Polybion Syrup?
Osto-Polybion Syrup is manufactured by P&G. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Osto-Polybion Syrup delivered?
Osto-Polybion Syrup is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Osto-Polybion Syrup, Quick facts

Salt
Vitamin D3 (200IU/5ml) + Cyanocobalamin (2.5mcg/5ml) + Calcium (210mg/5ml)
Form
syrup
Best price
₹277 (₹0.92 per ml)
Prescription
Not required (OTC)
Brand
Procter & Gamble Health Ltd
Manufacturer
P&G
Therapeutic class
Vitamin and mineral supplement and Vitamin supplement
Drug class
Vitamin D / calcium supplement and B-complex vitamin
Habit forming
No
Variants
syrup syrup 300ML
Delivery
Standard across India

References

The information on Osto-Polybion Syrup is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Osto-Polybion Syrup.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.