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Unison Pharmaceuticals - Tablet - 10 S
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Chlorthalidone + Cilnidipine + Telmisartan
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Telmiride Trio 12.5 Tablet is used for this medicine is used in the treatment of high blood pressure, heart failure, fluid retention, angina and diabetic kidney disease.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated October 2026
Telmiride Trio 12.5 Tablet contains Chlorthalidone + Cilnidipine + Telmisartan. It belongs to the Water tablet, Calcium channel blocker and Angiotensin receptor blocker / ACE inhibitor class of medicines.
This medicine combines 3 active ingredients: Chlorthalidone, Cilnidipine and Telmisartan. Chlorthalidone helps your kidneys remove surplus salt and water, which reduces swelling and lowers blood pressure. Cilnidipine relaxes the muscle in the walls of your blood vessels so they widen, which lowers blood pressure and eases the work of the heart. Telmisartan relaxes and widens your blood vessels by blocking a hormone that narrows them, so your heart does not have to push as hard and your blood pressure falls.
Swallow the tablet whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it in the morning. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe dehydration, a sharp fall in blood pressure and dangerous salt imbalances. It can cause a severe fall in blood pressure and a dangerously slow or irregular heartbeat. It can cause a severe fall in blood pressure, with dizziness, fainting and a fast or slow pulse. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Telmiride Trio are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Take it in the morning so that passing urine does not disturb your sleep. Your doctor will check your salts and kidney function with blood tests — do not skip them. Report muscle cramps, marked weakness, confusion or an irregular heartbeat; these can be signs your potassium or sodium has fallen. In hot weather or during an illness with vomiting or loose motions, tell your doctor — you may become dehydrated quickly. Ankle swelling is the commonest reason people stop this medicine — tell your doctor, as there are ways to manage it. Tell your doctor if your chest pain becomes more frequent or more severe after starting. Swollen, tender or overgrown gums should be reported; good brushing and regular dental care reduce the risk. Stand up slowly for the first few days — dizziness on rising is common when you start or your dose goes up. Stop and seek urgent care if your lips, tongue, face or throat swell, or you have difficulty breathing. A persistent dry, tickly cough can be caused by the ACE inhibitor group; tell your doctor rather than stopping on your own, as an alternative exists. Your doctor will check your kidney function and potassium after starting and after any dose change. Do not use salt substitutes containing potassium without asking your doctor.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people who are unable to pass urine, or who are severely dehydrated. Not for people with very low blood pressure or with severe narrowing of the aortic valve. Must not be used in pregnancy — it can seriously harm the developing baby. Not for people with narrowing of both kidney arteries, or a history of swelling of the face and throat caused by this group of medicines.
Anti-inflammatory painkillers blunt the effect and can strain the kidneys. Lithium and digoxin levels are affected; tell your doctor if you take either. Potassium-sparing types must not be combined with potassium supplements without supervision. Grapefruit juice raises the level of some of these medicines in the blood — avoid it. Tell your doctor about other blood pressure medicines, and about simvastatin in particular. Anti-inflammatory painkillers reduce the effect and can harm the kidneys when combined. Potassium supplements, potassium-sparing water tablets and salt substitutes can push potassium too high. Lithium levels rise when taken with these medicines.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
People taking Telmiride Trio are often asked to check these from time to time. Your doctor decides which and how often.

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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.