Zita Pio Met 1000 Tablet

Composition of Zita Pio Met 1000 Tablet

Zita Pio Met 1000 Tablet contains Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 1000 mg (as metformin hydrochloride) tablet. It belongs to the DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide class of medicines.

Uses of Zita Pio Met 1000 Tablet

Type 2 diabetes mellitus: to improve glycaemic control in adults when diet and exercise plus other antidiabetic medicines are not adequate

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves insulin sensitivity
• Reduces hepatic glucose output
• Helps achieve better HbA1c control in type 2 diabetes

How Zita Pio Met 1000 Tablet works

Sitagliptin (DPP-4 inhibitor) increases incretin hormones, which raise insulin release and reduce glucagon after meals. Metformin reduces liver glucose production and improves insulin sensitivity. Pioglitazone (TZD) increases insulin sensitivity in muscle and adipose tissue, improving glucose uptake.

How to take Zita Pio Met 1000 Tablet

Oral tablet; take exactly as prescribed. Usually taken with meals to reduce stomach upset; swallow whole with water. Monitor blood glucose regularly; do not stop abruptly without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zita Pio Met as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zita Pio Met than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zita Pio Met 1000 Tablet

Most side effects of Zita Pio Met are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal discomfort
• headache
• dizziness
• peripheral oedema (swelling)
• weight gain
• upper respiratory tract infection

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zita Pio Met 1000 Tablet

Warnings and precautions

For type 2 diabetes only; not for type 1 diabetes or diabetic ketoacidosis. Metformin may rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, alcoholism, or hypoxia; assess renal function before and during treatment and stop temporarily before iodinated contrast/surgery as advised. Pioglitazone can cause fluid retention and may worsen heart failure; monitor for rapid weight gain/shortness of breath. Risk of hypoglycaemia increases when used with insulin or sulfonylureas. Sitagliptin has been associated with pancreatitis and severe joint pain; seek care for severe abdominal pain. Use caution in liver disease; monitor liver enzymes. Periodic vitamin B12 monitoring may be needed with long-term metformin.

Interactions with other medicines

Alcohol (increases lactic acidosis risk with metformin), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate/acetazolamide), cationic drugs eliminated by renal secretion (e.g., cimetidine), insulin and sulfonylureas (increased hypoglycaemia risk), corticosteroids/thyroid hormones/diuretics (may raise glucose), rifampicin (may reduce pioglitazone effect), gemfibrozil (may increase pioglitazone levels)

How to store Zita Pio Met 1000 Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Manufacturer and class

Manufacturer:

GLENMARK PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide