Zita Pio Met 500 Tablet

Composition of Zita Pio Met 500 Tablet

Zita Pio Met 500 Tablet contains Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride). It belongs to the DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide class of medicines.

Uses of Zita Pio Met 500 Tablet

Type 2 diabetes mellitus—adjunct to diet and exercise to improve glycaemic control in adults when single/dual therapy is inadequate.

Key benefits

• improves blood sugar control in type 2 diabetes
• reduces fasting and post-meal glucose
• enhances insulin sensitivity
• supports HbA1c reduction
• helps when dual therapy is insufficient

How Zita Pio Met 500 Tablet works

Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity. Sitagliptin (a DPP-4 inhibitor) increases incretin levels, enhancing glucose-dependent insulin release and reducing glucagon. Pioglitazone (a thiazolidinedione) improves insulin sensitivity in muscle and adipose tissue.

How to take Zita Pio Met 500 Tablet

Tablet for oral use. Take exactly as prescribed, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Regularly monitor blood glucose/HbA1c as advised.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zita Pio Met as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zita Pio Met than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zita Pio Met 500 Tablet

Most side effects of Zita Pio Met are mild and settle as the body adjusts. Reported side effects include:

• nausea
• diarrhoea
• abdominal discomfort
• headache
• upper respiratory tract infection
• dizziness
• weight gain
• oedema (swelling)
• hypoglycaemia (especially with other antidiabetics)
• increased risk of fractures

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zita Pio Met 500 Tablet

Warnings and precautions

Prescription-only antidiabetic. Metformin: risk of lactic acidosis—avoid in severe renal impairment; assess kidney function before and during therapy; temporarily stop before/after iodinated contrast or major surgery as advised. Pioglitazone: may cause/worsen heart failure due to fluid retention—contraindicated in NYHA class III/IV; monitor for rapid weight gain, oedema, breathlessness; may increase fracture risk; monitor liver enzymes. Sitagliptin: rare pancreatitis/hypersensitivity—seek care for severe abdominal pain or rash. Use caution in elderly, dehydration, liver disease; maintain diet/exercise.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, insulin/sulfonylureas (increased hypoglycaemia), diuretics/corticosteroids/sympathomimetics (may worsen glycaemic control), gemfibrozil (increases pioglitazone levels), rifampicin (reduces pioglitazone levels), digoxin (levels may increase with pioglitazone), carbonic anhydrase inhibitors like topiramate (may increase acidosis risk with metformin).

How to store Zita Pio Met 500 Tablet

Store below 25°C in a dry place. Protect from moisture and light. Keep out of reach of children.

Manufacturer and class

Manufacturer:

GLENMARK PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide