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Prescription requiredGlenmark PharmaceuticalsAntidiabetic
Zita Pio Met 500 Tablet
Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride)
₹174MRP ₹1835% offIn stock
Order on WhatsAppDelivered across India in about 3–5 days, Chennai next day. ₹49 delivery, free above ₹999.
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Zita Pio Met 500 Tablet is used for type 2 diabetes mellitus—adjunct to diet and exercise to improve glycaemic control in adults when single/dual therapy is inadequate.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride)
Available variants: tablet 100mg + 15mg + 500mg 10`S
Best price: ₹174 (₹17.39 per tablet)
MRP: ₹183
Prescription: Required
Manufacturer: GLENMARK PHARMACEUTICALS
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Same salt, lower price
Medicines with the same active ingredient and strength as Zita Pio Met 500 Tablet.
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Zita Pio Met 500 Tablet
tablet - 100mg + 15mg + 500mg - 10 S
₹174
₹17.39 per tablet
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GLENMARK PHARMACEUTICALS · tablet - 500 mg - 10 S · Rx
Save 12%₹153
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- Sitaverse Mp Forte Tab
VERSE LIFESCIENCES · tablet - 500mg + 15mg + 100mg - 10 S · Rx
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₹16.39 per tablet
Same salt, different brand — what does that mean?
A substitute contains the same active ingredient (salt), in the same strength, as Zita Pio Met 500 Tablet. The medicine inside is the same — the brand name, manufacturer and price are what differ.
All medicines sold in India, branded or generic, must meet the quality standards set by the national drug regulator (CDSCO). A lower price does not mean lower quality.
Please confirm with your doctor or pharmacist before switching brands — they will check that the strength and form match your prescription.
Composition of Zita Pio Met 500 Tablet
Zita Pio Met 500 Tablet contains Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride). It belongs to the DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide class of medicines.
Uses of Zita Pio Met 500 Tablet
Type 2 diabetes mellitus—adjunct to diet and exercise to improve glycaemic control in adults when single/dual therapy is inadequate.
Key benefits
- improves blood sugar control in type 2 diabetes
- reduces fasting and post-meal glucose
- enhances insulin sensitivity
- supports HbA1c reduction
- helps when dual therapy is insufficient
How Zita Pio Met 500 Tablet works
Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity. Sitagliptin (a DPP-4 inhibitor) increases incretin levels, enhancing glucose-dependent insulin release and reducing glucagon. Pioglitazone (a thiazolidinedione) improves insulin sensitivity in muscle and adipose tissue.
How to take Zita Pio Met 500 Tablet
Tablet for oral use. Take exactly as prescribed, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Regularly monitor blood glucose/HbA1c as advised.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine may cause low blood sugar, particularly if you also take other diabetes medicines. It may cause low blood sugar and marked stomach upset. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Zita Pio Met 500 Tablet
Most side effects of Zita Pio Met are mild and settle as the body adjusts. Reported side effects include:
- nausea
- diarrhoea
- abdominal discomfort
- headache
- upper respiratory tract infection
- dizziness
- weight gain
- oedema (swelling)
- hypoglycaemia (especially with other antidiabetics)
- increased risk of fractures
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Zita Pio Met 500 Tablet
| Pregnancy | Consult doctor (generally not recommended; insulin is preferred in pregnancy). |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Avoid |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Warnings and precautions
Prescription-only antidiabetic. Metformin: risk of lactic acidosis—avoid in severe renal impairment; assess kidney function before and during therapy; temporarily stop before/after iodinated contrast or major surgery as advised. Pioglitazone: may cause/worsen heart failure due to fluid retention—contraindicated in NYHA class III/IV; monitor for rapid weight gain, oedema, breathlessness; may increase fracture risk; monitor liver enzymes. Sitagliptin: rare pancreatitis/hypersensitivity—seek care for severe abdominal pain or rash. Use caution in elderly, dehydration, liver disease; maintain diet/exercise.
Do not take Zita Pio Met if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.
Interactions with other medicines
Alcohol (increases lactic acidosis risk), iodinated contrast media, insulin/sulfonylureas (increased hypoglycaemia), diuretics/corticosteroids/sympathomimetics (may worsen glycaemic control), gemfibrozil (increases pioglitazone levels), rifampicin (reduces pioglitazone levels), digoxin (levels may increase with pioglitazone), carbonic anhydrase inhibitors like topiramate (may increase acidosis risk with metformin).
How to store Zita Pio Met 500 Tablet
Store below 25°C in a dry place. Protect from moisture and light. Keep out of reach of children.
Expert advice for Zita Pio Met 500 Tablet
It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them. Take it with the first mouthful of your meal so it can act on that meal. Expect some wind in the first weeks; it usually settles. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.
Manufacturer and class
- Manufacturer:
- GLENMARK PHARMACEUTICALS
- Therapeutic class:
- Antidiabetic
- Drug class:
- DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide
Substitutes for Zita Pio Met 500 Tablet
Medicines with the same active ingredient (Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Zita Pio Met 500 Tablet |
|---|---|---|---|
| Sitazit-Trio 500 mg TabletGLENMARK PHARMACEUTICALS | tablet · 10`S | ₹153 | 12% cheaper |
| Sitaverse Mp Forte TabletVERSE LIFESCIENCES | tablet · 10`S | ₹164 | 6% cheaper |
| Glura Mp 500 TabletERIS LIFE SCIENCES PVT LTD | tablet · 10`S | ₹182 | 5% more |
| Sitadoc Mp 500 TabletElbrit LIfe Sciences | tablet · 15`S | ₹214 | 23% more |
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Zita Pio Met 500 Tablet FAQs
What is Zita Pio Met 500 Tablet used for?
Zita Pio Met 500 Tablet is commonly used for Type 2 diabetes mellitus—adjunct to diet and exercise to improve glycaemic control in adults when single/dual therapy is inadequate. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Zita Pio Met 500 Tablet?
Zita Pio Met 500 Tablet contains Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Zita Pio Met 500 Tablet?
Tablet for oral use. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Zita Pio Met 500 Tablet work?
Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity.
Is Zita Pio Met 500 Tablet a prescription medicine?
Yes. Zita Pio Met 500 Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Zita Pio Met 500 Tablet?
The side effects reported most often with Zita Pio Met are nausea, diarrhoea, abdominal discomfort, headache, upper respiratory tract infection. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Zita Pio Met 500 Tablet be taken during pregnancy?
Consult doctor (generally not recommended; insulin is preferred in pregnancy). Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Zita Pio Met.
Can I drink alcohol while taking Zita Pio Met 500 Tablet?
Avoid
What if I miss a dose of Zita Pio Met 500 Tablet?
Take it as soon as you remember.
Is Zita Pio Met 500 Tablet habit forming?
No. Zita Pio Met 500 Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Zita Pio Met 500 Tablet?
Sitazit-Trio 500 mg Tablet has the same active ingredient and strength and is listed from ₹153 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Zita Pio Met 500 Tablet cost on PingMeDoc Pharmacy?
Zita Pio Met 500 Tablet starts at ₹174 (MRP ₹183) on PingMeDoc Pharmacy. Available in tablet 100mg + 15mg + 500mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Zita Pio Met 500 Tablet?
Zita Pio Met 500 Tablet is manufactured by GLENMARK PHARMACEUTICALS. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Zita Pio Met 500 Tablet delivered?
Zita Pio Met 500 Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Zita Pio Met 500 Tablet, Quick facts
- Salt
- Sitagliptin 100 mg + Pioglitazone 15 mg + Metformin 500 mg (as Metformin Hydrochloride)
- Form
- tablet
- Best price
- ₹174 (₹17.39 per tablet)
- MRP
- ₹183
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Brand
- GLENMARK PHARMACEUTICALS
- Manufacturer
- GLENMARK PHARMACEUTICALS
- Therapeutic class
- Antidiabetic
- Drug class
- DPP-4 inhibitor + Thiazolidinedione (TZD) + Biguanide
- Habit forming
- No
- Variants
- tablet 100mg + 15mg + 500mg 10`S
- Delivery
- Standard across India
References
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered medical practitioner. It does not replace your own doctor's advice.
- Manufacturer labeling/pack insert, established medical literature (drug monographs)
- CDSCO/Indian regulatory guidance, standard pharmacology references
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Zita Pio Met 500 Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.