
Ace Revelol 25/2.5
IPCA Laboratories Ltd - 10 S
Prescription required
Sacubitril (49mg) + Valsartan (51mg)
Sacumada 100 Tablet is used for treatment of chronic heart failure (particularly heart failure with reduced ejection fraction, HFrEF) to reduce the risk of cardiovascular death and hospitalization.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Medicines with the same active ingredient and strength as Sacumada 100 Tablet.
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Sacumada 100 Tablet
tablet - 14 S
₹407
₹29.06 per tablet
LARENON · tablet - 50 mg - 14 S · Rx
₹274
₹19.55 per tablet
ZYDUS HEALTHCARE PHARMA · tablet - 50 mg - 10 S · Rx
₹226
₹22.57 per tablet
MSN LABORATORIES · tablet - 14 S · Rx
₹339
₹24.21 per tablet
A substitute contains the same active ingredient (salt), in the same strength, as Sacumada 100 Tablet. The medicine inside is the same — the brand name, manufacturer and price are what differ.
All medicines sold in India, branded or generic, must meet the quality standards set by the national drug regulator (CDSCO). A lower price does not mean lower quality.
Please confirm with your doctor or pharmacist before switching brands — they will check that the strength and form match your prescription.
Sacumada 100 Tablet contains Sacubitril (49mg) + Valsartan (51mg). It belongs to the ARNI (Angiotensin Receptor Neprilysin Inhibitor) class of medicines.
Sacubitril inhibits neprilysin, increasing levels of beneficial natriuretic peptides leading to vasodilation and reduced fluid overload. Valsartan blocks angiotensin II (AT1) receptors, reducing vasoconstriction and aldosterone effects. Together they lower cardiac workload and improve heart failure outcomes.
Take as prescribed by the doctor, usually twice daily, with or without food. Swallow the tablet whole with water; do not crush or chew. Dose is titrated based on blood pressure, kidney function and tolerance; do not stop abruptly without medical advice.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause a severe fall in blood pressure, with dizziness, fainting and a fast or slow pulse. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Sacumada are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended (contraindicated in pregnancy); consult doctor immediately if pregnant or planning pregnancy. |
|---|---|
| Breastfeeding | Hefcard 49mg/51mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. |
| Alcohol | Use with caution; alcohol may increase dizziness and blood pressure lowering effects. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Alsectan 49mg/51mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Alsectan 49mg/51mg Tablet may be needed. Please consult your doctor.Regular blood pressure monitoring is recommended. No dose adjustment is needed in patients with mild to moderate kidney disease. |
| Liver | Sacumada 100 Tablet should be used with caution in patients with liver disease. Dose adjustment of Sacumada 100 Tablet may be needed. Please consult your doctor.No dose adjustment is recommended in patients with mild to moderate liver disease. |
| Habit forming | No |
Contraindicated with a history of angioedema related to ACE inhibitors/ARBs. Do not use together with an ACE inhibitor; maintain a 36-hour washout when switching from an ACE inhibitor due to angioedema risk. Use with caution in low blood pressure, dehydration, kidney impairment, hyperkalaemia, severe liver disease; monitor BP, serum potassium and renal function. Avoid in pregnancy; can harm the unborn baby. Seek emergency care for facial/lip/tongue swelling or breathing difficulty.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be used in pregnancy — it can seriously harm the developing baby. Not for people with narrowing of both kidney arteries, or a history of swelling of the face and throat caused by this group of medicines.
ACE inhibitors (contraindicated; 36-hour washout required),aliskiren (avoid in diabetes; caution in renal impairment),potassium supplements/potassium-sparing diuretics (e.g., spironolactone, eplerenone, amiloride) and salt substitutes (hyperkalaemia),NSAIDs (may worsen kidney function),lithium (increased lithium levels/toxicity),other antihypertensives/diuretics (additive hypotension)
Store below 30°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.
Blood pressure medicines work only while you take them — do not stop because you feel well. Tell your doctor at once if you become pregnant or are planning a pregnancy. Keep a home blood-pressure record if your doctor has asked for one.
Medicines with the same active ingredient (Sacubitril (49mg) + Valsartan (51mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Sacumada 100 Tablet |
|---|---|---|---|
| Arnx 50 mg TabletZYDUS HEALTHCARE PHARMA | tablet · 10`S | ₹226 | 45% cheaper |
| Arnx 100 mg TabletZYDUS HEALTHCARE PHARMA | tablet · 10`S | ₹257 | 37% cheaper |
| Saculysin 50 mg TabletLARENON | tablet · 14`S | ₹274 | 33% cheaper |
| Sacutan 100 TabletMSN LABORATORIES | tablet · 14`S | ₹339 | 17% cheaper |
| Arnicor 100 TabletCIPLA LIMITED | tablet · 10`S | ₹340 | 16% cheaper |
| Sacustart-100 mg TabletSANZ PHARMACEUTICALS | tablet · 14`S | ₹392 | 4% cheaper |
| Arnipin 100 TabletLUPIN LAB | tablet · 10`S | ₹396 | 3% cheaper |
| Azmarda 100 mg TabletJB CHEMICALS | tablet · 14`S | ₹939 | 131% more |
| Vymada 100 mg TabletNovartis India Ltd | tablet · 2X14`S | ₹1,889 | 364% more |

IPCA Laboratories Ltd - 10 S
Prescription required
IPCA Laboratories Ltd - 10 S
Prescription required
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IPCA Laboratories Ltd - 10 S
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Prescription required
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Prescription required
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Micro Labs - Cream - 15 gm - 15 G
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The information on Sacumada 100 Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.