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Prescription requiredSanz PharmaceuticalsCardiovascular (Heart failure)
Sacustart-100 mg Tablet
Sacubitril 49 mg + Valsartan 51 mg (as Sacubitril/Valsartan) per tablet
₹373MRP ₹392In stock
Order on WhatsAppDelivery across India. Free above ₹999; ₹49 from ₹499, ₹99 below. Chennai express delivery is chargeable.
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Sacustart-100 mg Tablet is used for treatment of chronic heart failure (especially heart failure with reduced ejection fraction, HFrEF) to reduce risk of cardiovascular death and hospitalization.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Licensed pharmacyPharmacist-verified orderDelivered across India
Key details
Salt: Sacubitril 49 mg + Valsartan 51 mg (as Sacubitril/Valsartan) per tablet
Available variants: tablet 100 mg 14`S
Best price: ₹373 (₹26.63 per tablet)
MRP: ₹392
Prescription: Required
Manufacturer: SANZ PHARMACEUTICALS
Ordering notes
Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Same salt, lower price
Medicines with the same active ingredient and strength as Sacustart-100 mg Tablet.
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Sacustart-100 mg Tablet
tablet - 100 mg - 14 S
₹373
₹26.63 per tablet
- Arnx 50MG Tab
ZYDUS HEALTHCARE PHARMA · tablet - 50 mg - 10 S · Rx
Save 19%₹214
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- Sacutan 100 Tab 14S
MSN LABORATORIES · tablet - 49mg + 51mg - 14 S · Rx
₹354
₹25.30 per tablet
Same salt, different brand — what does that mean?
A substitute contains the same active ingredient (salt), in the same strength, as Sacustart-100 mg Tablet. The medicine inside is the same — the brand name, manufacturer and price are what differ.
All medicines sold in India, branded or generic, must meet the quality standards set by the national drug regulator (CDSCO). A lower price does not mean lower quality.
Please confirm with your doctor or pharmacist before switching brands — they will check that the strength and form match your prescription.
Composition of Sacustart-100 mg Tablet
Sacustart-100 mg Tablet contains Sacubitril 49 mg + Valsartan 51 mg (as Sacubitril/Valsartan) per tablet. It belongs to the ARNI (Angiotensin receptor neprilysin inhibitor) class of medicines.
Uses of Sacustart-100 mg Tablet
- Treatment of chronic heart failure (especially heart failure with reduced ejection fraction
- HFrEF) to reduce risk of cardiovascular death and hospitalization
Key benefits
- Reduces risk of cardiovascular death in HFrEF
- Decreases hospitalization due to heart failure
- Improves symptoms and exercise tolerance in chronic heart failure
- Helps reduce cardiac remodeling and fluid overload
How Sacustart-100 mg Tablet works
Sacubitril inhibits neprilysin, increasing levels of natriuretic peptides which promote vasodilation, natriuresis and reduced cardiac remodeling. Valsartan blocks angiotensin II (AT1) receptors, lowering vasoconstriction and aldosterone effects. Together they reduce cardiac workload and improve heart failure outcomes.
How to take Sacustart-100 mg Tablet
Oral tablet. Take exactly as prescribed, usually twice daily, with or without food, at the same time each day. If switching from an ACE inhibitor, maintain a 36-hour washout before starting. Do not stop abruptly without medical advice.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine can cause a severe fall in blood pressure, with dizziness, fainting and a fast or slow pulse. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Sacustart-100 mg Tablet
Most side effects of Sacustart-100 mg are mild and settle as the body adjusts. Reported side effects include:
- Low blood pressure (hypotension)
- dizziness
- high potassium (hyperkalemia)
- kidney function changes (increased creatinine)
- cough
- diarrhoea
- headache
- angioedema (rare but serious)
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Sacustart-100 mg Tablet
| Pregnancy | Not recommended (contraindicated in pregnancy) |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Use with caution (may increase dizziness and low blood pressure) |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Use with caution if you have liver disease — your doctor may adjust the dose or monitor your liver function. |
| Habit forming | No |
Warnings and precautions
Contraindicated with concomitant ACE inhibitors (requires 36-hour washout) and in history of angioedema related to ACEi/ARB. Do not use in pregnancy; can harm the fetus. Use caution in low blood pressure, dehydration, kidney impairment, severe liver disease, and diabetes. Monitor blood pressure, serum potassium and renal function periodically; risk of hyperkalemia and worsening renal function. Seek urgent care for swelling of face/lips/tongue or breathing difficulty (angioedema).
Do not take Sacustart-100 mg if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be used in pregnancy — it can seriously harm the developing baby. Not for people with narrowing of both kidney arteries, or a history of swelling of the face and throat caused by this group of medicines.
Interactions with other medicines
ACE inhibitors (contraindicated; 36-hour washout),aliskiren (avoid in diabetes; caution in renal impairment),potassium supplements/salt substitutes and potassium-sparing diuretics (e.g., spironolactone/eplerenone/amiloride),NSAIDs (may worsen kidney function),lithium (may increase lithium levels),other antihypertensives/diuretics (additive hypotension)
How to store Sacustart-100 mg Tablet
Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.
Expert advice for Sacustart-100 mg Tablet
Blood pressure medicines work only while you take them — do not stop because you feel well. Tell your doctor at once if you become pregnant or are planning a pregnancy. Keep a home blood-pressure record if your doctor has asked for one.
Manufacturer and class
- Manufacturer:
- SANZ PHARMACEUTICALS
- Therapeutic class:
- Cardiovascular (Heart failure)
- Drug class:
- ARNI (Angiotensin receptor neprilysin inhibitor)
Substitutes for Sacustart-100 mg Tablet
Medicines with the same active ingredient (Sacubitril 49 mg + Valsartan 51 mg (as Sacubitril/Valsartan) per tablet). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Sacustart-100 mg Tablet |
|---|---|---|---|
| Arnx 50 mg TabletZYDUS HEALTHCARE PHARMA | tablet · 10`S | ₹214 | 42% cheaper |
| Arnx 100 mg TabletZYDUS HEALTHCARE PHARMA | tablet · 10`S | ₹268 | 28% cheaper |
| Arnicor 100 TabletCIPLA LIMITED | tablet · 10`S | ₹323 | 13% cheaper |
| Sacutan 100 TabletMSN LABORATORIES | tablet · 14`S | ₹354 | 5% cheaper |
| Arnipin 100 TabletLUPIN LAB | tablet · 10`S | ₹376 | 1% more |
| Sacumada 100 TabletIPCA LABORATORIES LTD` | tablet · 14`S | ₹387 | 4% more |
| Azmarda 100 mg TabletJB CHEMICALS | tablet · 14`S | ₹811 | 118% more |
| Vymada 100 mg TabletNovartis India Ltd | tablet · 2X14`S | ₹1,795 | 381% more |
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Sacustart-100 mg Tablet FAQs
What is Sacustart-100 mg Tablet used for?
Sacustart-100 mg Tablet is commonly used for Treatment of chronic heart failure (especially heart failure with reduced ejection fraction, HFrEF) to reduce risk of cardiovascular death and hospitalization. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Sacustart-100 mg Tablet?
Sacustart-100 mg Tablet contains Sacubitril 49 mg + Valsartan 51 mg (as Sacubitril/Valsartan) per tablet. If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Sacustart-100 mg Tablet?
Oral tablet. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Sacustart-100 mg Tablet work?
Sacubitril inhibits neprilysin, increasing levels of natriuretic peptides which promote vasodilation, natriuresis and reduced cardiac remodeling.
Is Sacustart-100 mg Tablet a prescription medicine?
Yes. Sacustart-100 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Sacustart-100 mg Tablet?
The side effects reported most often with Sacustart-100 mg are Low blood pressure (hypotension), dizziness, high potassium (hyperkalemia), kidney function changes (increased creatinine), cough. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Sacustart-100 mg Tablet be taken during pregnancy?
Not recommended (contraindicated in pregnancy) Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Sacustart-100 mg.
Can I drink alcohol while taking Sacustart-100 mg Tablet?
Use with caution (may increase dizziness and low blood pressure)
What if I miss a dose of Sacustart-100 mg Tablet?
Take it as soon as you remember.
Is Sacustart-100 mg Tablet habit forming?
No. Sacustart-100 mg Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Sacustart-100 mg Tablet?
Arnx 50 mg Tablet has the same active ingredient and strength and is listed from ₹214 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Sacustart-100 mg Tablet cost on PingMeDoc Pharmacy?
Sacustart-100 mg Tablet starts at ₹373 (MRP ₹392) on PingMeDoc Pharmacy. Available in tablet 100 mg 14`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Sacustart-100 mg Tablet?
Sacustart-100 mg Tablet is manufactured by SANZ PHARMACEUTICALS. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Sacustart-100 mg Tablet delivered?
Sacustart-100 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.
Sacustart-100 mg Tablet, Quick facts
- Salt
- Sacubitril 49 mg + Valsartan 51 mg (as Sacubitril/Valsartan) per tablet
- Form
- tablet
- Best price
- ₹373 (₹26.63 per tablet)
- MRP
- ₹392
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Brand
- SANZ PHARMACEUTICALS
- Manufacturer
- SANZ PHARMACEUTICALS
- Therapeutic class
- Cardiovascular (Heart failure)
- Drug class
- ARNI (Angiotensin receptor neprilysin inhibitor)
- Habit forming
- No
- Variants
- tablet 100 mg 14`S
- Delivery
- Standard across India
References
The information on Sacustart-100 mg Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.
- Manufacturer labeling/SmPC for sacubitril-valsartan,Established medical literature and heart failure guidelines,Drug safety information for ARBs/ARNI (class labeling)
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Sacustart-100 mg Tablet.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.