Xmet Trio 500/0.2/2 Tablet

Composition of Xmet Trio 500/0.2/2 Tablet

Xmet Trio 500/0.2/2 Tablet contains Glimepiride (2mg) + Metformin (500mg) + Voglibose (0.2mg). It belongs to the Sulfonylurea, Biguanide and Oral anti-diabetic class of medicines.

Uses of Xmet Trio 500/0.2/2 Tablet

Treatment of Type 2 diabetes mellitus

Key benefits

• In Treatment of Type 2 diabetes mellitus Xmet-Trio 500/0.2/2 Tablet ER helps control high blood glucose levels after meals and supports better overall diabetes management. The medicine lowers the risk of serious complications of diabetes
• such as kidney damage
• vision problems
• nerve issues
• and limb loss. It also helps reduce the risk of death from cardiovascular disease in people with type 2 diabetes who already have heart disease. Regular use of Xmet-Trio 500/0.2/2 Tablet ER
• along with a healthy diet and exercise
• supports long-term health and helps you maintain a more stable and active life.

How Xmet Trio 500/0.2/2 Tablet works

Xmet-Trio 500/0.2/2 Tablet ER is a combination of three antidiabetic medicines: glimepiride, metformin, and voglibose. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea that works by increasing the amount of insulin released by the pancreas to lower the blood glucose. Metformin is a biguanide that lowers glucose production in the liver, delays glucose absorption from the intestines, and increases the body's sensitivity to insulin. Voglibose is an alpha-glucosidase inhibitor that prevents the breakdown of complex sugars into simple sugars such as glucose. This prevents the blood glucose levels from rising to very high levels after meals.

How to take Xmet Trio 500/0.2/2 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xmet-Trio 500/0.2/2 Tablet ER is to be taken on an empty stomach.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Xmet-Trio 500/0.2/2 Tablet ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar and marked stomach upset. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Xmet Trio 500/0.2/2 Tablet

Most side effects of Xmet Trio 500/0.2/2 are mild and settle as the body adjusts. Reported side effects include:

• Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Xmet Trio 500/0.2/2 Tablet

Warnings and precautions

If you feel shaky, sweaty, confused or unusually hungry, take sugar, glucose or a sweet drink at once and tell your doctor — these are signs your blood sugar has fallen too low. Do not skip meals while on this medicine — a missed meal is the commonest cause of a low-sugar episode. Carry glucose, sugar or sweets with you, and tell the people you live and work with what a low-sugar episode looks like. Older people and people with kidney trouble are more likely to have low sugar, and may need a smaller dose. Stomach upset is common in the first two weeks and usually settles; taking it with food helps. Tell your doctor before any surgery or a scan that uses contrast dye — this medicine is usually stopped for a short time around them. Stop and seek urgent care if you develop deep rapid breathing, severe weakness, muscle pain or vomiting with cold clammy skin. This is rare but serious. Long-term use can lower vitamin B12, so your doctor may check it from time to time. If a low-sugar episode happens while on an alpha-glucosidase inhibitor such as voglibose or acarbose, use glucose — ordinary sugar and sweets work more slowly. Tell your doctor about any new swelling of the ankles, breathlessness or sudden weight gain.

Do not take Xmet Trio 500/0.2/2 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine.

Interactions with other medicines

Many medicines change how strongly this works — tell your doctor about aspirin, blood thinners, antifungals, sulfa antibiotics and beta blockers in particular. Beta blockers can mask the warning signs of low blood sugar. Tell your doctor about water tablets, steroids, and any contrast dye scan. Alcohol increases the risk of the rare acid build-up and should be limited. Low blood sugar is more likely when combined with insulin or a sulfonylurea.

How to store Xmet Trio 500/0.2/2 Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Xmet Trio 500/0.2/2 Tablet

Xmet-Trio 500/0.2/2 Tablet ER can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines or alcohol, or if you delay or miss a meal. Carry a sugar source with you for immediate relief. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice). Individuals with severe renal or hepatic impairment should not take Xmet-Trio 500/0.2/2 Tablet ER. This medicine works best when used along with proper diet and exercise.

Manufacturer and class

Manufacturer:

GLENMARK PHARMACEUTICALS

Therapeutic class:

ANTI DIABETIC

Drug class:

Sulfonylurea, Biguanide and Oral anti-diabetic